Clinical diagnosis and treatment of pediatric anti-N-methyl-D-aspartate receptor encephalitis: A single center retrospective study
Clinical diagnosis and treatment of pediatric anti-N-methyl-D-aspartate receptor encephalitis: A single center retrospective study
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DOI：
10.3892/etm.2018.6329
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发表时间：
2018-08-01
影响因子：
2.7
通讯作者：
Tan, Lihong
中科院分区：
文献类型：
--
作者：
Sai, Yang;Zhang, Xiao;Tan, Lihong
本回顾性研究的目的是探讨小儿抗N-甲基-D-天冬氨酸受体（抗NMDAR）脑炎的诊断、治疗和预后。本研究共纳入23例抗NMDAR脑炎患儿。对临床资料、实验室检查结果、影像学检查、治疗结果和随访记录进行回顾和分析。共有8名患者出现前驱症状，包括发热、咳嗽和呕吐。临床症状包括癫痫、惊厥、共济失调、昏迷、运动障碍、个人行为改变和幻觉。20例患者以运动障碍或癫痫发作为首发症状，3例患者以个人行为改变和幻觉为首发症状。此外，>6岁儿童的精神症状比
The aim of the present retrospective study was to investigate the diagnosis, treatment and prognosis of pediatric anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. A total of 23 pediatric patients with anti-NMDAR encephalitis were included in the present study. The clinical data, laboratory test results, imaging examination, treatment outcomes, and follow-up records were reviewed and analyzed. A total of 8 patients exhibited prodromal symptoms, including fever, cough, and vomiting. Clinical symptoms included epilepsy, convulsions, ataxia, coma, dyskinesia, personal behavior change and hallucinations. A total of 20 cases had the initial neurologic symptoms of dyskinesia or seizure, whereas 3 cases exhibited psychiatric symptoms of personal behavior change and hallucinations. Furthermore, pediatric patients >6 years old had more psychiatric symptoms than those