KL-6 mucin in metastatic liver cancer tissues from primary colorectal carcinoma.
KL-6 mucin in metastatic liver cancer tissues from primary colorectal carcinoma.
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发表时间：
2009-01
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通讯作者：
Keming Zhang;Wei Tang;Xian-Jun Qu;Q. Guo;Y. Inagaki;Y. Seyama;H. Abe;R. Gai;N. Kokudo;Y. Sugawara;M. Nakata;M. Makuuchi
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作者：
Keming Zhang;Wei Tang;Xian-Jun Qu;Q. Guo;Y. Inagaki;Y. Seyama;H. Abe;R. Gai;N. Kokudo;Y. Sugawara;M. Nakata;M. Makuuchi
背景/目的KL-6粘蛋白是携带KL-6抗体识别的唾液酸化糖表位的MUC 1。本研究旨在评估结直肠癌和肝细胞癌肝转移组织中KL-6粘蛋白的亚细胞定位。方法收集56例结直肠癌肝转移患者和92例肝细胞癌肝切除患者的组织标本。使用KL-6抗体对组织进行免疫组织化学分析。结果56例转移性肝癌组织中KL-6粘蛋白均呈阳性表达，而非癌组织中均无阳性表达。在癌细胞的周膜和/或细胞质中观察到所有染色。相反，在92例肝细胞癌患者的癌组织或非癌组织中均未观察到KL-6粘蛋白染色。结论KL-6粘蛋白可能是大肠癌肝转移的一个指标。此外，KL-6粘蛋白的检测可能有助于区分肝细胞癌和转移性肝癌。
BACKGROUND/AIMS KL-6 mucin is MUC1 bearing sialylated carbohydrate epitopes recognized by KL-6 antibody. This study aimed to assess subcellular localization of KL-6 mucin in liver metastatic tissues from colorectal carcinoma and hepatocellular carcinoma tissues. METHODOLOGY Tissue samples were collected from 56 patients with liver metastasis of colorectal carcinoma and 92 patients with hepatocellular carcinoma who underwent a hepatectomy. Tissues were subjected to immunohistochemical analysis using KL-6 antibody. RESULTS All 56 cases with metastatic liver cancer showed positive staining for KL-6 mucin in cancer tissues but not in non-cancerous tissues. All staining was observed in the circumferential membrane and/or cytoplasm of the cancer cells. In contrast, no staining for KL-6 mucin was observed in either cancerous or non-cancerous tissues of the 92 patients with hepatocellular carcinoma. CONCLUSIONS KL-6 mucin may be an indicator for liver metastasis of colorectal carcinoma. Additionally, detection of KL-6 mucin may be helpful in distinguishing hepatocellular carcinoma from metastatic liver cancer.