Mechanism and therapeutic potential of tumor-immune symbiosis in glioblastoma.

Mechanism and therapeutic potential of tumor-immune symbiosis in glioblastoma.
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DOI:
10.1016/j.trecan.2022.04.010
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发表时间:
2022-10
期刊:
影响因子:
18.4
通讯作者:
Chen, Peiwen
Chen, Peiwen
中科院分区:
医学1区
文献类型:
--
作者:
Pang, Lizhi;Khan, Fatima;Heimberger, Amy B.;Chen, Peiwen

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胶质母细胞瘤(GBM)是人类成年人中最具侵略性和致命的脑肿瘤形式。髓样谱系细胞,包括巨噬细胞,小胶质细胞,髓样衍生的抑制细胞和中性粒细胞是GBM肿瘤微环境(TME)中最常见的细胞类型,导致肿瘤进展。新兴的实验证据表明,癌细胞与髓样细胞之间的共生相互作用对于GBM中的肿瘤生长和免疫疗法至关重要。这篇综述涵盖了癌细胞如何塑造髓样细胞介导的免疫抑制性TME的分子机制,并相互地,这种髓样细胞如何影响GBM肿瘤进展和免疫疗法效率。此外,这篇综述讨论了肿瘤-T细胞共生,并总结了拦截这种共同依赖性GBM的免疫治疗策略。
Glioblastoma (GBM) is the most aggressive and lethal form of brain tumor in human adults. The myeloid lineage cells, including macrophages, microglia, myeloid-derived suppressor cells, and neutrophils are the most frequent types of cells in the GBM tumor microenvironment (TME) that contribute to tumor progression. Emerging experimental evidence indicates that symbiotic interactions between cancer cells and myeloid cells are critical for tumor growth and immunotherapy resistance in GBM. This review covers the molecular mechanisms for how cancer cells shape a myeloid cell-mediated immunosuppressive TME, and reciprocally, how such myeloid cells affect tumor progression and immunotherapy efficiency in GBM. Moreover, this review discusses tumor-T-cell symbiosis and summarizes immunotherapeutic strategies intercepting this co-dependency in GBM.
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