Gene transcription in the zebrafish embryo: regulators and networks
Gene transcription in the zebrafish embryo: regulators and networks
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DOI：
10.1093/bfgp/elt044
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发表时间：
2014-03-01
影响因子：
4
通讯作者：
Straehle, Uwe
中科院分区：
文献类型：
--
作者：
Ferg, Marco;Armant, Olivier;Straehle, Uwe
基因表达的精确时空调控是脊椎动物机体发育、维持和再生的关键过程。相当大比例的脊椎动物基因组编码控制遗传信息转录成信使核糖核酸的基因。斑马鱼特别适合于研究发育过程中基因表达控制的基因调控网络，因为它的透明胚胎的外部发育，以及这个模型系统可用的日益复杂的遗传操作工具。本文以斑马鱼发育中的脊髓为例，综述了斑马鱼顺式调控模块、转录调控及其整合到基因调控网络中的研究进展。
The precise spatial and temporal control of gene expression is a key process in the development, maintenance and regeneration of the vertebrate body. A substantial proportion of vertebrate genomes encode genes that control the transcription of the genetic information into mRNA. The zebrafish is particularly well suited to investigate gene regulatory networks underlying the control of gene expression during development due to the external development of its transparent embryos and the increasingly sophisticated tools for genetic manipulation available for this model system. We review here recent data on the analysis of cis-regulatory modules, transcriptional regulators and their integration into gene regulatory networks in the zebrafish, using the developing spinal cord as example.