Involvement of the supramammillary nucleus in aversive conditioning.
Involvement of the supramammillary nucleus in aversive conditioning.
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DOI：
10.1037/0735-7044.119.5.1290
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发表时间：
2005-10
影响因子：
1.9
通讯作者：
Y. Yasoshima;T. R. Scott;Takashi Yamamoto
中科院分区：
文献类型：
--
作者：
Y. Yasoshima;T. R. Scott;Takashi Yamamoto
条件性味觉厌恶（CTA）的保留和恢复机制尚未完全确定。作者通过追踪即早期基因 c-fos 和 zif268 的表达来探索相关的皮质下前脑区域。基于内脏的 CTA 和基于躯体的抑制性回避 (IA) 后，乳头上核 (SuM) 被激活。在调节之前，SuM 的兴奋性毒性损伤不会导致 CTA 和 IA 的获取中断，但会加速 CTA 和 IA 的消失。相比之下，CTA 调节后的病变不会损害保留或恢复。目前的研究表明，SuM 在检索过程中被记忆引起的不适所激活，这表明它在抵抗长期厌恶记忆的消失方面发挥着作用。
Mechanisms for the retention and retrieval of conditioned taste aversions (CTAs) have yet to be fully defined. The authors explored relevant subcortical forebrain regions by tracking the expression of immediate early genes, c-fos and zif268. The supramammillary nucleus (SuM) was activated following both viscerally based CTA and somatically based inhibitory avoidance (IA). Excitotoxic lesions of the SuM before conditioning caused no disruption of acquisition but accelerated the extinction of both the CTA and IA. In contrast, lesions after CTA conditioning did not impair retention or retrieval. The present study indicates that the SuM is activated by memory-elicited discomfort during retrieval, suggesting that it plays a role in resisting the extinction of a long-term aversive memory.