The effect of ambient air pollution on respiratory health of school children: a panel study.
The effect of ambient air pollution on respiratory health of school children: a panel study.
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环境空气污染对学童呼吸健康的影响：一项小组研究。
DOI：
10.1186/1476-069x-7-16
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发表时间：
2008-05-14
期刊：
影响因子：
--
通讯作者：
Brown L
中科院分区：
文献类型：
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作者：
Epton MJ;Dawson RD;Brooks WM;Kingham S;Aberkane T;Cavanagh JA;Frampton CM;Hewitt T;Cook JM;McLeod S;McCartin F;Trought K;Brown L
流行病学研究已经确定了空气微粒污染对呼吸系统的不利影响。我们的目的是研究木材燃烧产生的环境颗粒物空气污染对新西兰克赖斯特彻奇学龄学生的健康影响，并探索该人群中尿液和呼出气体冷凝物暴露的生物标志物的效用。2004年冬天，对93名住在一所城市学校寄宿公寓的男学生（26名患有哮喘）进行了小组研究。连续监测室内外污染数据。对肺功能（FEV1和峰值流量）和症状进行了纵向评估，并对高污染暴露的生物标志物（尿1-羟基芘）和影响（呼气冷凝水（EBC） pH值和过氧化氢浓度）进行了事件研究。空气污染的峰值水平对哮喘学生的肺功能有很小但有统计学意义的影响，而对健康学生没有影响。污染对健康学生和哮喘学生气道炎症和氧化应激均无显著影响。呼吸道症状的轻微增加与高污染暴露有关。与低污染控制天数相比，尿中1-羟基芘水平与污染事件有关。环境木烟颗粒物空气污染对健康学龄学生肺功能无显著影响，但对呼吸道症状影响较小。哮喘学生的肺功能受到污染峰值的影响很小。尿中1-羟基芘有可能作为该人群暴露于木材烟雾的生物标志物；然而，测定EBC pH值和过氧化氢对于评估空气污染对人口健康的影响似乎没有用处。本文中提出的一些数据先前已发表在Kingham及其同事的《大气环境》杂志上，2006年1月；《环境科学》，2007年3月1日；374(1):51-9（尿羟芘数据）。
Adverse respiratory effects of particulate air pollution have been identified by epidemiological studies. We aimed to examine the health effects of ambient particulate air pollution from wood burning on school-age students in Christchurch, New Zealand, and to explore the utility of urine and exhaled breath condensate biomarkers of exposure in this population. A panel study of 93 male students (26 with asthma) living in the boarding house of a metropolitan school was undertaken in the winter of 2004. Indoor and outdoor pollution data was continuously monitored. Longitudinal assessment of lung function (FEV1 and peak flow) and symptoms were undertaken, with event studies of high pollution on biomarkers of exposure (urinary 1-hydroxypyrene) and effect (exhaled breath condensate (EBC) pH and hydrogen peroxide concentration). Peak levels of air pollution were associated with small but statistically significant effects on lung function in the asthmatic students, but not healthy students. No significant effect of pollution could be seen either on airway inflammation and oxidative stress either in healthy students or students with asthma. Minor increases in respiratory symptoms were associated with high pollution exposure. Urinary 1-hydroxypyrene levels were raised in association with pollution events by comparison with low pollution control days. There is no significant effect of ambient wood-smoke particulate air pollution on lung function of healthy school-aged students, but a small effect on respiratory symptoms. Asthmatic students show small effects of peak pollution levels on lung function. Urinary 1-hydroxypyrene shows potential as a biomarker of exposure to wood smoke in this population; however measurement of EBC pH and hydrogen peroxide appears not to be useful for assessment of population health effects of air pollution. Some of the data presented in this paper has previously been published in Kingham and co-workers Atmospheric Environment, 2006 Jan; 40: 338–347 (details of pollution exposure), and Cavanagh and co-workers Sci Total Environ. 2007 Mar 1;374(1):51-9 (urine hydroxypyrene data).