Numerical Simulation of Concussive-Generated Cortical Spreading Depolarization to Optimize DC-EEG Electrode Spacing for Noninvasive Visual Detection.
Numerical Simulation of Concussive-Generated Cortical Spreading Depolarization to Optimize DC-EEG Electrode Spacing for Noninvasive Visual Detection.
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DOI：
10.1007/s12028-021-01430-x
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发表时间：
2022-06
影响因子：
3.5
通讯作者：
Jones SC
中科院分区：
文献类型：
--
作者：
Hund SJ;Brown BR;Lemale CL;Menon PG;Easley KA;Dreier JP;Jones SC
Cortical Spreading Depolarization (SD) is a propagating depolarization wave of neurons and glial cells in the cerebral gray matter. SD occurs in all forms of severe acute brain injury as documented using invasive detection methods. Based on many experimental studies of mechanical brain deformation and concussion, the occurrence of SDs in human concussion has often been hypothesized. However, this hypothesis cannot be confirmed in humans as SDs can only be detected with invasive detection methods that would require either a craniotomy or a burr hole to be performed on athletes. Typical electroencephalography (EEG) electrodes, placed on the scalp, can detect the possible presence of SD but have not been able to accurately and reliably identify SDs. To explore the possibility of a non-invasive method to resolve this hurdle, we developed a finite element numerical model that simulates scalp voltage changes that are induced by a brain-surface SD. We then compared our simulation results with retrospectively evaluated data in aneurysmal subarachnoid hemorrhage (aSAH) patients from Drenckhahn et al. (Brain 135:853, 2012). The ratio of peak scalp to simulated peak cortical voltage, Vscalp/Vcortex, was 0.0735, whereas the ratio from the retrospectively evaluated data was 0.0316 (0.0221, 0.0527) [median (1st quartile, 3rd quartile), n = 161, p < 0.001, one sample Wilcoxon signed rank test]. These differing values provide validation because their differences can be attributed to differences in shape between concussive- and aSAH-SDs, as well as the inherent limitations in human study voltage measurements. This simulated scalp surface potential was used to design a virtual scalp detection array. Error analysis and visual reconstruction showed that 1 cm is the optimal electrode spacing to visually identify the propagating scalp voltage from a cortical SD. Electrode spacings of 2 cm and above produce distorted images and high errors in the reconstructed image. Our analysis suggests that concussive (and other) SDs can be detected from the scalp, which could confirm SD occurrence in human concussion, provide concussion diagnosis based on an underlying physiological mechanism, and lead to non-invasive SD detection in the setting of severe acute brain injury.
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影响因子：
14.5
作者：
Dreier, Jens P.;Woitzik, Johannes;Strong, Anthony J.
通讯作者：
Strong, Anthony J.
影响因子：
3.9
作者：
Bruce, Jared;Echemendia, Ruben;Sisco, Amber
通讯作者：
Sisco, Amber
影响因子：
3.3
作者：
Broglio, Steven P.;Cantu, Robert C.;McLeod, Tamara C. Valovich
通讯作者：
McLeod, Tamara C. Valovich
DOI：
10.1093/brain/awp102
发表时间：
2009-07
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Dreier JP;Major S;Manning A;Woitzik J;Drenckhahn C;Steinbrink J;Tolias C;Oliveira-Ferreira AI;Fabricius M;Hartings JA;Vajkoczy P;Lauritzen M;Dirnagl U;Bohner G;Strong AJ;COSBID study group
通讯作者：
COSBID study group
影响因子：
11.2
作者：
Dohmen, Christian;Sakowitz, Oliver W.;Graf, Rudolf
通讯作者：
Graf, Rudolf