THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION
THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION
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DOI：
10.1073/pnas.41.11.849
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发表时间：
1955-01-01
影响因子：
11.1
通讯作者：
JERNE, NK
中科院分区：
文献类型：
--
作者：
JERNE, NK
提出了一种抗体形成的理论，该理论假定动物血液中自发存在少量抗体分子，这些抗体分子可以对抗动物可以反应的所有抗原，并将这种特定的球蛋白分子从循环中携带到细胞中，这些分子可以诱导更多同类的产生。该理论解释了血液中大量正常球蛋白的存在，解释了天然抗体的存在，解释了抗原颗粒表面在抗体诱导中所起的主导作用，解释了免疫过程中抗体特性的变化（通过自然选择），解释了部分抗体产生过程中的指数增长，解释了在没有抗原的情况下抗体的持续产生，解释了增强现象。对于自身抗体的缺乏，对于免疫麻痹和半抗原抑制，以及对于遗忘反应。
A theory of antibody formation is proposed which postulates the spontaneous presence, in the blood of an animal, of small numbers of antibody molecules against all antigens to which the animal can respond, and delegates to the antigen the sole role of carrying such specific globulin molecules from the circulation into cells in which these molecules can induce the production of more of their kind. The theory offers an explanation for the presence in blood of a large pool of normal globulins, for the presence of natural antibodies, for the dominant part played by the surface of antigen particles in antibody induction, for the change in character of antibody during the course of immunization (by natural selection), for the exponential increase during part of antibody production, for a continued production of antibody in the absence of the antigen, for the booster phenomenon, for the absence of auto-antibodies, for immunological paralysis and haptenic inhibition, and for the anamnestic reaction.