Visuospatial Functioning in the Primary Progressive Aphasias.
Visuospatial Functioning in the Primary Progressive Aphasias.
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DOI：
10.1017/s1355617717000984
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发表时间：
2018-03
期刊：
影响因子：
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通讯作者：
Gorno-Tempini ML
中科院分区：
文献类型：
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作者：
Watson CL;Possin K;Allen IE;Hubbard HI;Meyer M;Welch AE;Rabinovici GD;Rosen H;Rankin KP;Miller Z;Santos-Santos MA;Kramer JH;Miller BL;Gorno-Tempini ML
本研究的目的是确定是否三个主要的原发性进行性失语症（PPA）的变种将显示不同的配置文件的视觉空间认知的措施。我们假设，在需要视觉空间和视觉记忆能力的任务中，逻辑开放变体将具有最大的困难。PPA患者（n = 156），诊断使用当前的标准，和对照组进行了测试的电池测试挖掘不同方面的视觉空间认知。我们比较了组的整体视觉空间因素，建设，即时回忆，延迟回忆，执行功能的复合材料，并在个人测试。进行了横向和纵向比较，调整了疾病严重程度，年龄和教育。logopenic变量有显着较低的分数的视觉空间因素和最受损的分数的所有复合材料。非流利的变体有显着的困难，所有的视觉空间的复合材料，除了延迟回忆，区分他们从logopenic的变体。相比之下，语义变量表现不佳，只有延迟回忆的视觉信息。随着时间的推移，logopenic和nonfluent变量的数字复制性能下降，而在语义变量，这种技能是显着保留。这种广泛的检查PPA变体的视觉空间任务的性能巩固了一些以前的研究结果，例如，视觉刺激的延迟回忆增加了logopenic变体PPA和nonfluent变体PPA变体之间的鉴别诊断的价值，并阐明了共同的机制，在变体的语言和非语言缺陷的可能性。此外，这是第一个研究PPA变体随时间推移的视觉空间功能的研究。
The aim of this study was to identify whether the three main primary progressive aphasia (PPA) variants would show differential profiles on measures of visuospatial cognition. We hypothesized that the logopenic variant would have the most difficulty across tasks requiring visuospatial and visual memory abilities. PPA patients (n = 156), diagnosed using current criteria, and controls were tested on a battery of tests tapping different aspects of visuospatial cognition. We compared the groups on an overall visuospatial factor; construction, immediate recall, delayed recall, and executive functioning composites; and on individual tests. Cross-sectional and longitudinal comparisons were made, adjusted for disease severity, age, and education. The logopenic variant had significantly lower scores on the visuospatial factor and the most impaired scores on all composites. The nonfluent variant had significant difficulty on all visuospatial composites except the delayed recall, which differentiated them from the logopenic variant. In contrast, the semantic variants performed poorly only on delayed recall of visual information. The logopenic and nonfluent variants showed decline in figure copying performance over time, whereas in the semantic variant, this skill was remarkably preserved. This extensive examination of performance on visuospatial tasks in the PPA variants solidifies some previous findings, for example, delayed recall of visual stimuli adds value in differential diagnosis between logopenic variant PPA and nonfluent variant PPA variants, and illuminates the possibility of common mechanisms that underlie both linguistic and non-linguistic deficits in the variants. Furthermore, this is the first study that has investigated visuospatial functioning over time in the PPA variants.