Cross-national comparison of paediatric antibiotic use in Norway, Portugal and Hungary
Cross-national comparison of paediatric antibiotic use in Norway, Portugal and Hungary
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DOI：
10.1111/bcpt.13198
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发表时间：
2019-06-01
影响因子：
3.1
通讯作者：
Blix, Hege Salvesen
中科院分区：
文献类型：
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作者：
Benko, Ria;Matuz, Maria;Blix, Hege Salvesen
对匈牙利、挪威和葡萄牙的儿科（0-19岁）抗生素使用情况进行了一项跨国比较，以探索和比较这三个欧洲国家儿科抗生素使用的规模和模式。从国家数据库中检索2014年的门诊护理全身抗生素使用（ATC：J 01）。主要结果指标是每年每个儿童居民的抗菌包数量（包/儿童/年），并进一步按年龄组分层。儿科抗生素使用在匈牙利达到峰值，为1.3包/儿童/年，其次是葡萄牙（0.8包）和挪威（0.3包）。这一排名得到保留，在5至9岁和10至14岁年龄组中最为突出。不同儿科年龄组的抗生素使用模式在各国之间也有很大差异。与匈牙利和葡萄牙相比，窄谱青霉素在挪威的所有儿科年龄亚组中更常用。与挪威相比，匈牙利和葡萄牙儿童在所有儿科亚组中广泛使用较新的广谱头孢菌素类和大环内酯类，而挪威青少年通常使用四环素类。与挪威相比，匈牙利和葡萄牙儿科抗生素使用的规模和模式非常不同。在匈牙利和葡萄牙，高抗生素暴露和广谱青霉素的高消耗开始于儿童时期，这是儿科全科医生的责任。
A cross-national comparison was performed on paediatric (0-19 years) antibiotic use in Hungary, Norway and Portugal to explore and compare the scale and pattern of paediatric antibiotic use in these three European countries. Ambulatory care systemic antibiotic use (ATC: J01) was retrieved from national databases for year 2014. The main outcome measure was number of antibacterial packages per child inhabitant per year (packages/child/year) and was further stratified by age groups. Paediatric antibiotic use peaked in Hungary with 1.3 packages/child/year, followed by Portugal (0.8) and Norway (0.3). This ranking was retained and was most prominent in the 5- to 9-year and 10- to 14-year age groups. The pattern of antibiotic use in different paediatric age groups varied also substantially between countries. Narrow-spectrum penicillins were much commonly used in Norway in all paediatric age subgroups in comparison with Hungary and Portugal. Newer, broad-spectrum cephalosporins and macrolides were widely prescribed for Hungarian and Portuguese children in all paediatric subgroups in contrast to Norway, while tetracyclines were commonly prescribed for Norwegian adolescents. The scale and pattern of paediatric antibiotic use in Hungary and Portugal were very different compared with Norway. The high antibiotic exposure and the high consumption of broad-spectrum penicillins begin in childhood in Hungary and Portugal which underpins the responsibility of paediatric GPs.