Association between TP53 gene Arg72Pro polymorphism and Wilms' tumor risk in a Chinese population.
Association between TP53 gene Arg72Pro polymorphism and Wilms' tumor risk in a Chinese population.
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DOI：
10.2147/ott.s131014
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发表时间：
2017
影响因子：
4
通讯作者：
Liu GC
中科院分区：
文献类型：
--
作者：
Fu W;Zhuo ZJ;Jia W;Zhu J;Zhu SB;Lin ZF;Wang FH;Xia H;He J;Liu GC
肾母细胞瘤是最常见的儿童恶性肿瘤之一，在全球儿童癌症中排名第四。TP 53是一个重要的肿瘤抑制基因，它编码一个53 kDa的蛋白质p53。p53通过调节细胞周期和凋亡以及维持DNA完整性来保护免受癌症。TP 53基因具有高度多态性。一些TP 53基因多态性被认为与癌症风险相关。其中，非同义多态性Arg 72 Pro（rs 1042522 C>G）与癌症风险的相关性研究最为广泛;然而，很少有研究调查其对肾母细胞瘤的影响。由于p53在细胞周期调控中的核心作用，TP 53基因Arg 72 Pro多态性也是这种儿科癌症的一个很好的潜在候选易感基因座。我们采用Taqman方法对145例中国儿童癌症患者和531例中国儿童非癌症对照进行了基因分型。总体而言，我们的结果表明TP 53基因Arg 72 Pro多态性与Wilms肿瘤之间缺乏相关性。在分层分析中，我们发现CG/GG基因型携带者与CC基因型携带者相比，在小于18个月的儿童中具有显著增加的肾母细胞瘤风险（校正比值比=2.04，95%置信区间=1.003-4.13，P=0.049）。我们的研究表明TP 53基因Arg 72 Pro多态性可能对中国儿童肾母细胞瘤的风险有微弱的、与年龄相关的影响。这些发现需要在其他更大样本量的人群中进一步验证。
Wilms’ tumor is one of the most prevalent pediatric malignancies, ranking fourth in childhood cancer worldwide. TP53 is a critical tumor suppressor gene, which encodes a 53 kDa protein, p53. The p53 functions to protect against cancer by regulating cell cycle and apoptosis and maintaining DNA integrity. TP53 gene is highly polymorphic. Several TP53 gene polymorphisms have been considered to be associated with cancer risk. Of them, a nonsynonymous polymorphism, Arg72Pro (rs1042522 C>G), has been most extensively studied for the association with cancer risk; however, few studies have investigated its effect on Wilms’ tumor. Because of the central role of p53 in cell cycle control, the TP53 gene Arg72Pro polymorphism is also a good potential candidate predisposition locus for this pediatric cancer. We genotyped this polymorphism in 145 patients and 531 cancer-free controls recruited from Chinese children by Taqman methodology. Overall, our result suggested a lack of association between the TP53 gene Arg72Pro polymorphism and Wilms’ tumor. In the stratified analysis, we found that carriers of CG/GG genotypes had a significantly increased Wilms’ tumor risk in children not older than 18 months (adjusted odds ratio =2.04, 95% confidence interval =1.003–4.13, P=0.049) compared with CC genotype carriers. Our study indicated that the TP53 gene Arg72Pro polymorphism may have a weak, age-related effect on Wilms’ tumor risk in Chinese children. These findings need further validations in other populations with larger sample size.