Iron-Catalyzed Ortho C-H Homoallylation of Aromatic Ketones with Methylenecyclopropanes
Iron-Catalyzed Ortho C-H Homoallylation of Aromatic Ketones with Methylenecyclopropanes
复制标题
铁催化芳香酮与亚甲基环丙烷的邻位 C-H 均烯化反应
DOI：
10.1021/jacs.1c00237
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发表时间：
2021
影响因子：
15
通讯作者：
Kakiuchi Fumitoshi
中科院分区：
文献类型：
--
作者：
Kimura Naoki;Katta Shiori;Kitazawa Yoichi;Kochi Takuya;Kakiuchi Fumitoshi
我们在这里报道了仅使用催化量的 Fe(PMe3)4 芳族酮与亚甲基环丙烷 (MCP) 的 C-H 同烯丙基化反应。多种芳香酮和MCP适用于通过三元环的区域选择性断裂选择性形成邻位高烯丙基化芳香酮的反应。高烯丙基化产物适合进一步精制，提供官能化的 1,2-二氢萘。
We report here a C–H homoallylation reaction of aromatic ketones with methylenecyclopropanes (MCPs) only using a catalytic amount of Fe(PMe3)4. A variety of aromatic ketones and MCPs are applicable to the reaction to form ortho-homoallylated aromatic ketones selectively via regioselective scission of the three-membered rings. The homoallylated products are amenable to further elaborations, providing functionalized 1,2-dihydronaphthalenes.