Coronaviruses: an overview of their replication and pathogenesis.
Coronaviruses: an overview of their replication and pathogenesis.
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DOI：
10.1007/978-1-4939-2438-7_1
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Perlman, Stanley
中科院分区：
文献类型：
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作者：
Fehr, Anthony R;Perlman, Stanley
冠状病毒（cov）是包膜正义RNA病毒，其特征是从其表面突出的棒状刺，异常大的RNA基因组和独特的复制策略。冠状病毒在哺乳动物和鸟类中引起多种疾病，从牛和猪的肠炎和鸡的上呼吸道疾病到可能致命的人类呼吸道感染。本文对冠状病毒进行了简要介绍，讨论了冠状病毒的复制和致病性，以及目前的防治策略。我们还讨论了高致病性严重急性呼吸综合征冠状病毒（SARS-CoV）和最近发现的中东呼吸综合征冠状病毒（MERS-CoV）的爆发。
Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, an unusually large RNA genome, and a unique replication strategy. Coronaviruses cause a variety of diseases in mammals and birds ranging from enteritis in cows and pigs and upper respiratory disease in chickens to potentially lethal human respiratory infections. Here we provide a brief introduction to coronaviruses discussing their replication and pathogenicity, and current prevention and treatment strategies. We also discuss the outbreaks of the highly pathogenic Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the recently identified Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV).