Evaluating the Hypothalamic-Pituitary-Thyroid (HPT) Axis in Mice
Evaluating the Hypothalamic-Pituitary-Thyroid (HPT) Axis in Mice
复制标题
DOI：
10.1007/978-1-4939-7902-8_13
复制
发表时间：
2018-01-01
期刊：
影响因子：
--
通讯作者：
Wondisford, F. E.
中科院分区：
文献类型：
--
作者：
Wondisford, F. E.
由于实验动物的基因组变得更容易操作，许多小鼠模型已经被开发出来，以了解体内甲状腺激素的作用。甲状腺激素作用的一个主要部位是HPT轴。虽然有几种方法可以提供对小鼠HPT轴的详细了解，但许多作者选择只包括关于该轴的粗略数据，这可能导致关于体内甲状腺激素作用的错误结论。提出了一种评价小鼠HPT轴的标准方案。
As the genome of experimental animals has become easier to manipulate, a number of mouse models have been developed to understand in vivo thyroid hormone action. A major site of thyroid hormone action is the HPT axis. While several methods are available that provide a detailed understanding of the HPT axis in mice, many authors choose to include only cursory data about this axis, which can lead to erroneous conclusions about in vivo thyroid hormone action. A standard protocol is proposed to evaluate the HPT axis in mice.