Testicular teratoma demanded in-depth pathological exploration to rule out malignancy: A pediatric case report
Testicular teratoma demanded in-depth pathological exploration to rule out malignancy: A pediatric case report
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睾丸畸胎瘤需要深入病理探查以排除恶性肿瘤：儿科病例报告
DOI：
10.1002/iju5.12050
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Hayashi Yutaro
中科院分区：
文献类型：
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作者：
Moritoki Yoshinobu;Mizuno Kentaro;Kato Taiki;Hamamoto Shuzo;Hattori Hideo;Ito Yasuhiko;Saitoh Shinji;Yasui Takahiro;Hayashi Yutaro
青春期前睾丸肿瘤可分为良性和恶性。虽然大多数睾丸畸胎瘤是良性的，但一些未成熟的病例包括恶变或与卵黄囊瘤的混合型，偶尔，排除恶性肿瘤是具有挑战性的。病例介绍我们报告一例7个月大的婴儿发生未成熟睾丸畸胎瘤，其甲胎蛋白水平在睾丸切除术后连续升高。由于不能排除恶性肿瘤，我们进行了全身成像和深入的病理检查。GLYPICAN 3、OCT 3/4和SOX 2染色显示无恶性肿瘤证据。病人最后被诊断为良性未成熟畸胎瘤，并已无复发3年。结论在这里，我们描述的情况下报告，以及所有的综合诊断测试，我们进行了，以排除恶性成分。
Introduction Prepubertal testicular tumors can be both benign and malignant. Although most testicular teratomas are benign, some immature cases include malignant transformation or the mixed type with yolk sac tumor and, occasionally, it is challenging to rule out malignancy. Case presentation We present a case of immature testicular teratoma in a 7‐month‐old infant, whose alpha‐fetoprotein level was sequentially elevated following orchidectomy. Since malignancy could not be ruled out, we performed whole body imaging and in‐depth pathological exploration. GLYPICAN3, OCT3/4, and SOX2 staining revealed no evidence of malignancy. The patient was finally diagnosed with benign immature teratoma, and has been free from recurrence for 3 years. Conclusion Here, we describe the case report, as well as all the comprehensive diagnostic tests that we performed in order to rule out the malignant component.