Quantification of myocardial blood flow using (201)Tl SPECT and population-based input function.
Quantification of myocardial blood flow using (201)Tl SPECT and population-based input function.
复制标题
使用 (201)Tl SPECT 和基于人群的输入函数对心肌血流量进行量化。
DOI：
10.1007/s12149-014-0888-8
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发表时间：
2014
影响因子：
2.6
通讯作者：
Hidehiro Iida
中科院分区：
文献类型：
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作者：
Kazuhiro Koshino;Kazuhito Fukushima;Masaji Fukumoto;Yuki Hori;Tetsuaki Moriguchi;Tsutomu Zeniya;Yoshihiro Nishimura;Keisuke Kiso;Hidehiro Iida
[目的]铊-201(201Tl)单光子发射计算机断层扫描(SPECT)是诊断缺血性心脏病的重要手段。心肌血流量(MBF)的绝对定量可能比半定量评估提供更多关于心肌灌注的有用信息。本研究旨在验证基于总体平均输入函数(STD-IF)和一点血液采样技术的201Tl心脏SPECT对MBF的定量。方法使用SPECT/CT扫描仪对11名健康志愿者进行201Tl发射和基于CT的衰减扫描。发射扫描期间的个体输入函数(IND-IF)基于动脉血样。STD-IF技术的验证如下：(1)确定了校准STD-IF的最佳时间，以最小化校准的STD-IF和IND-IF之间的差异。(2)组织时间-活度曲线(TTAC)建立在单组织房室模型的基础上，MBFtrue分别为0.50、1.0、1.5和2.0毫升/分/克，恒定分布体积为45毫升/毫升，以及IND-IF。每个受试者的伪STD-IF是使用留一法生成的。利用最佳校准时间和伪STD-IF，用放射自显影方法估算TTAC上的MBF值。(3)利用最优校正时间和MST对伪STD-IFS和IND-IFS的MBF值进行了比较。结果最佳校正时间和MST均为201Tl注射后20min。用IND-IF和伪STD-IF测定的全球MBF与心率-压力乘积呈显著正相关，R2=0.01R_2=0.01R_2=0.303；P&t；0.05.用伪性传播疾病-迭代函数系统测定区域血流量的平均百分比误差为0.69%±77.80%(−为12.80~14.25%)。使用IND-IF和伪STD-IF的局部MBF值之间没有显著差异。结论本研究证明，基于STD-IF和一点血样的所提出的技术提供了血流动力学合理的整体MBF值，并且区域MBF值与IND-IF相当。
ObjectivesThallium-201 (201Tl) single photon emission computed tomography (SPECT) is an important tool in the diagnosis of ischemic heart disease. Absolute quantification of myocardial blood flow (MBF) has the potential to provide more useful information on myocardial perfusion than semi-quantitative assessments. This study aimed to validate the quantification of MBF using201Tl cardiac SPECT based on a population-averaged input function (STD-IF) and one-point blood sample technique.Methods201Tl emission and computed tomography (CT)-based attenuation scans were performed on 11 healthy volunteers at rest using a SPECT/CT scanner. Individual input functions (IND-IFs) during the emission scans were based on arterial blood samples. The STD-IF technique was validated as follows: (1) optimal time to calibrate a STD-IF was determined to minimize differences between the calibrated STD-IF and the IND-IFs. (2) Tissue time-activity curves (TTACs) were generated based on a single-tissue compartment model for MBFtrue= 0.5, 1.0, 1.5, and 2.0 mL/min/g, a constant distribution volume of 45 mL/mL, and IND-IFs. The pseudo STD-IF for each subject was generated using the leave-one-out technique. Using the optimal calibration time and the pseudo STD-IFs, MBF values were estimated on the TTACs with an autoradiography method. Optimal mid-scan time (MST) with a fixed duration of 20 min was determined to minimize intersubject variation in estimated MBF errors, and (3) Global and regional MBF values estimated with pseudo STD-IFs were compared to those with IND-IFs using the optimal calibration time and MST.ResultsThe optimal calibration time and MST were both 20 min after201Tl injection. Global MBF determined using both IND-IFs and pseudo STD-IF showed significant correlations with rate-pressure products,R2= 0.645;p< 0.01 andR2= 0.303;p< 0.05, respectively. The mean percent error in regional MBF using pseudo STD-IFs was 0.69 ± 7.80 % (−12.80 to 14.25 %). No significant difference was observed between regional MBF values using IND-IFs and pseudo STD-IFs.ConclusionThis study demonstrated that the proposed technique based on a STD-IF and one-point blood sample provided hemodynamically reasonable global MBF values and the regional MBF values comparable to those with IND-IFs.