Evidence for complex genic interactions between conspecific chromosomes underlying hybrid female sterility in the Drosophila simulans clade.
Evidence for complex genic interactions between conspecific chromosomes underlying hybrid female sterility in the Drosophila simulans clade.
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模拟果蝇进化枝中杂交雌性不育的同种染色体之间复杂基因相互作用的证据。
DOI：
10.1093/genetics/137.1.191
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发表时间：
1994
期刊：
影响因子：
3.3
通讯作者：
Wu,CI
中科院分区：
文献类型：
--
作者：
Davis,AW;Noonburg,EG;Wu,CI
相似果蝇、毛里求斯果蝇和sechellia果蝇之间的F1杂种雌性是完全可育的。然而，我们已经发现，雌性不育可以观察到在F2回交雌性谁是纯合的D。simulans X染色体上的常染色体区域纯合。mauritiana或D. sechellia。结果表明，D. mauritiana常染色体（2或3）可引起雌性完全不育。simulans背景。同时存在的纯合区域从第二和第三染色体的D。然而，毛里求斯的疟疾几乎造成了完全的雌性不育，这不能用它们的个体效应来解释。D. sechellia可能显示出类似的模式。从相同的杂交，我们还获得了证据反对的作用，细胞质或母体的影响，造成这些物种之间的杂种雄性不育。与其他地方提出的结果，这些观察表明，在杂交背景中的同种基因之间的上位相互作用可能是最近分歧的物种之间的杂种不育的普遍模式。
F1 hybrid females between the sibling species Drosophila simulans, Drosophila mauritiana and Drosophila sechellia are completely fertile. However, we have found that female sterility can be observed in F2 backcross females who are homozygous for D. simulans X chromosomes and homozygous for autosomal regions from either D. mauritiana or D. sechellia. Our results indicate that neither D. mauritiana autosome (2 or 3) can cause complete female sterility in a D. simulans background. The simultaneous presence of homozygous regions from both the second and third chromosomes of D. mauritiana, however, causes nearly complete female sterility which cannot be accounted for by their individual effects. The two autosomes of D. sechellia may show a similar pattern. From the same crosses, we also obtained evidence against a role for cytoplasmic or maternal effects in causing hybrid male sterility between these species. Taken with the results presented elsewhere, these observations suggest that epistatic interactions between conspecific genes in a hybrid background may be the prevalent mode of hybrid sterility between recently diverged species.