Telomerase Therapy to Reverse Cardiovascular Senescence.
Telomerase Therapy to Reverse Cardiovascular Senescence.
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DOI：
10.14797/mdcj-11-3-172
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发表时间：
2015-07-01
影响因子：
--
通讯作者：
Cooke, John P
中科院分区：
文献类型：
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作者：
Nazari-Shafti, Timo Z;Cooke, John P
内皮细胞的细胞衰老在最终导致动脉粥样硬化斑块的血管病变的发展中起着重要作用。本综述重点关注导致血管疾病的内皮细胞和血管平滑肌细胞与年龄相关的变化，并讨论了可以使血管系统恢复活力从而预防或延缓动脉粥样硬化的潜在新靶点。
Cellular senescence of endothelial cells plays an important role in the development of vascular lesions that ultimately lead to an atherosclerotic plaque. This review focuses on the age-related changes of endothelial and vascular smooth muscle cells that contribute to vascular disease and discusses potential new targets that could rejuvenate the vascular system and thereby prevent or delay atherosclerosis.