Steroid control of muscle remodeling during metamorphosis in Manduca sexta.

Steroid control of muscle remodeling during metamorphosis in Manduca sexta.
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烟草天蛾变态过程中类固醇​​对肌肉重塑的控制。

DOI:
10.1002/(sici)1097-4695(199604)29:4
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发表时间:
1996
期刊:
Journal of neurobiology
影响因子:
--
通讯作者:
Truman,JW
Truman,JW
中科院分区:
--
文献类型:
--
作者:
Hegstrom,CD;Truman,JW

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在烟草天蛾(Manduca sexta)的变态过程中,腹部体壁肌肉DEO 1被重塑形成成体肌肉DE 5。肌肉DEO 1的变性涉及其收缩装置的解体,随后是肌核的变性。随着一些细胞核的退化,其他细胞核开始掺入5-溴脱氧尿苷(BrdU),表明细胞核增殖的开始。这种增殖最初在运动神经元接触肌肉残体的部位最为明显。参与肌肉重塑的发育事件是在类固醇激素,蜕皮激素的控制下。幼虫肌肉的收缩元素的损失需要蜕皮类固醇的prepupal峰的上升和下降,而随后的肌肉细胞核的损失是由蛹蜕皮后看到的蜕皮类固醇的轻微上升的影响。肌核BrdU的掺入取决于蜕皮激素的成人峰值和与运动神经元的接触。单侧轴突切断可以阻止原基内的增殖,但并不能阻止其随后在成人中分化为非常薄的肌肉。John Wiley & Sons,Inc.
During metamorphosis in the tobacco hornworm,Manduca sexta,the abdominal body‐wall muscle DEO1 is remodeled to form the adult muscle DE5. The degeneration of muscle DEO1 involves the dismantling of its contractile apparatus followed by the degeneration of muscle nuclei. As some nuclei are degenerating, others begin to incorporate 5‐bromodeoxyuridine (BrdU), indicating the onset of nuclear proliferation. This proliferation is initially most evident at the site where the motoneuron contacts the muscle remnant. The developmental events involved in muscle remodeling are under the control of the steroid hormones, the ecdysteroids. The loss of the contractile elements of the larval muscle requires the rise and fall of the prepupal peak of ecdysteroids, whereas the subsequent loss of muscle nuclei is influenced by the slight rise in ecdysteroids seen after pupal ecdysis. Incorporation of BrdU by muscle nuclei depends on both the adult peak of the ecdysteroids and contact with the motoneuron. Unilateral axotomy blocks proliferation within the rudiment, but it does not block its subsequent differentiation into a very thin muscle in the adult. © 1996 John Wiley & Sons, Inc.
DOI: --
发表时间: 1985
影响因子: 5.3
作者:
R. Levine;J. Truman
通讯作者: J. Truman
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DOI: --
发表时间: 1968
期刊:
影响因子: --
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DOI: 10.1083/jcb.37.2.462
发表时间: 1968-05
影响因子: 7.8
作者:
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发表时间: 1968-10
影响因子: 2.2
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发表时间: 1968
影响因子: --
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