PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in Carcinogenesis.
PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in Carcinogenesis.
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DOI：
10.1124/mol.118.112268
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发表时间：
2018-07
影响因子：
3.6
通讯作者：
Costa M
中科院分区：
文献类型：
--
作者：
Chen QY;Costa M
砷是一种天然存在的、普遍存在于地壳中的类金属。砷的无机形式具有高度毒性和致癌性，广泛存在于地球仪和整个环境中。作为国际癌症研究机构定义的1类人类致癌物，砷可导致多种人类癌症，包括肝癌、肺癌、膀胱癌、皮肤癌、肾癌和前列腺癌。砷诱导的致癌机制仍然难以捉摸，这篇综述特别关注PI 3 K/AKT/mTOR通路在促进癌症发展中的作用。除了发挥强大的致癌作用外，砷还因其对急性早幼粒细胞白血病的治疗作用而闻名。目前的文献表明，砷可以实现治疗以及致癌作用，这篇综述旨在研究砷的矛盾作用，特别是通过PI 3 K/AKT/mTOR通路。此外，对当前文献的全面综述揭示了未来研究的迫切需要，以确定和确定砷可以的确切条件，以及通过什么机制能够差异调节PI 3 K/AKT/mTOR通路，以最大限度地提高治疗效果并最大限度地降低砷的致癌性。
Arsenic is a naturally occurring, ubiquitous metalloid found in the Earth’s crust. In its inorganic form, arsenic is highly toxic and carcinogenic and is widely found across the globe and throughout the environment. As an International Agency for Research on Cancer–defined class 1 human carcinogen, arsenic can cause multiple human cancers, including liver, lung, urinary bladder, skin, kidney, and prostate. Mechanisms of arsenic-induced carcinogenesis remain elusive, and this review focuses specifically on the role of the PI3K/AKT/mTOR pathway in promoting cancer development. In addition to exerting potent carcinogenic responses, arsenic is also known for its therapeutic effects against acute promyelocytic leukemia. Current literature suggests that arsenic can achieve both therapeutic as well as carcinogenic effects, and this review serves to examine the paradoxical effects of arsenic, specifically through the PI3K/AKT/mTOR pathway. Furthermore, a comprehensive review of current literature reveals an imperative need for future studies to establish and pinpoint the exact conditions for which arsenic can, and through what mechanisms it is able to, differentially regulate the PI3K/AKT/mTOR pathway to maximize the therapeutic and minimize the carcinogenic properties of arsenic.
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影响因子：
3.8
作者：
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通讯作者：
Chen, Fei
影响因子：
5.3
作者：
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通讯作者：
Blenis, J
DOI：
10.1093/toxsci/kfp015
发表时间：
2009-06
期刊：
Toxicological sciences : an official journal of the Society of Toxicology
影响因子：
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作者：
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Duell EJ
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作者：
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通讯作者：
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DOI：
10.1016/j.bbrc.2011.09.102
发表时间：
2011-10-28
影响因子：
3.1
作者：
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通讯作者：
Jiang, Bing-Hua