To serotype or not to serotype: that is still the question.
To serotype or not to serotype: that is still the question.
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DOI：
10.1086/510862
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发表时间：
2007-03
期刊：
影响因子：
--
通讯作者：
A. Kapikian;Y. Hoshino
中科院分区：
文献类型：
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作者：
A. Kapikian;Y. Hoshino
在本期杂志中，Banerjee等人[1]关于G10P轮状病毒感染新生儿后的保护作用[11]的报告对轮状病毒疫苗学具有重要意义。新生儿轮状病毒感染的保护作用以前已经被各种研究者讨论过。在1983年澳大利亚的一项研究中，出生后14天内无症状轮状病毒脱落的新生儿，与对照组儿童相比，产后发生轮状病毒阳性腹泻的情况较少且较轻[2]。引起新生儿感染的可用菌株具有相同的电泳模式（此外，1株菌株被鉴定为“M样”[G3]菌株[3，4]），而引起新生儿后感染的菌株具有不同的模式。虽然血清型特征在当时还不容易获得，但现在的证据表明，无症状的新生儿G3感染有利于
In this issue of the Journal, the report by Banerjee et al. [1] on the postneonatal protective effect of a prior neonatal infection with G10P [11] rotavirus has important implications for rotavirus vaccinology. The protective efficacy of a neonatal rotavirus infection has been addressed previously by various investigators. In a 1983 Australian study, neonates with asymptomatic rotavirus shedding during the first 14 days of life developed fewer and lesssevere rotavirus-positive diarrhealillnesses postneonatally than did control children [2]. The available strains causing neonatal infection had identical electrophoretic patterns (in addition, 1 strain was identified as an "M-like" [G3] strain [3, 4]), whereas the strains causing postneonatal infection had varying patterns. Although serotypic characterization was not readily available at the time, evidence now indicates that asymptomatic neonatal G3 infections pro-