Measuring liability for schizophrenia using optimized antisaccade stimulus parameters.
Measuring liability for schizophrenia using optimized antisaccade stimulus parameters.
复制标题
使用优化的抗眼跳刺激参数来衡量精神分裂症的责任。
DOI：
10.1017/s0048577299980836
复制
发表时间：
1999
期刊：
影响因子：
3.7
通讯作者：
Clementz,BA
中科院分区：
文献类型：
--
作者：
McDowell,JE;Myles-Worsley,M;Coon,H;Byerley,W;Clementz,BA
The ability to identify unaffected gene carriers within families may be crucial to the success of schizophrenia genetics studies. Data collected from three family samples (N = 365) demonstrated that poor antisaccade performance is an exceptionally promising indicator of liability for schizophrenia. A particular antisaccade task version provides large separations (5–6 sigma) between proband and normal groups. Poor antisaccade performance alone correctly identified 70% of patients in California, Utah, and Micronesia schizophrenia samples. Twenty-five to 50% of these patients' nonpsychotic first-degree relatives also had poor antisaccade performance, yielding risk ratios around 20:1 for simplex and 50:1 for multiplex schizophrenia families. Poor antisaccade performance is associated with dorsolateral prefrontal cortex pathology, suggesting that dysfunction of this circuitry also may predispose individuals to developing this disease.
