Update on the Correlation Between Mitochondrial Dysfunction and Intervertebral Disk Degeneration
Update on the Correlation Between Mitochondrial Dysfunction and Intervertebral Disk Degeneration
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线粒体功能障碍与椎间盘退变之间相关性的最新进展
DOI：
10.1089/dna.2021.1012
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发表时间：
2022
影响因子：
3.1
通讯作者：
Xiaotao Wu
中科院分区：
文献类型：
--
作者：
Cong Zhang;Xin Peng;Feng Wang;Zhiyang Xie;Lu Chen;Xiaotao Wu
腰痛（LBP）是骨科门诊患者的常见疾病，影响各个年龄段的人群，部分患者可能发展为慢性腰痛。作为一种复杂的细胞器，线粒体不仅是能量工作站，还调节细胞衰老、凋亡和体内平衡。线粒体功能障碍通过影响多种病理生理过程来促进椎间盘退变，包括氧化应激、线粒体自噬、线粒体稳态、细胞衰老和细胞死亡。我们回顾了线粒体功能障碍与椎间盘退变（IDD）之间关系的分子机制，为利用药理学或组织工程方法治疗 IDD 提供理论基础。
Low back pain (LBP) is a common disorder in orthopedic outpatients, affecting people of all ages, and some patients may develop chronic LBP. As a complex organelle, mitochondria are not only energy workstations but also regulate cell senescence, apoptosis, and homeostasis. Mitochondrial dysfunction promotes disk degeneration by affecting a variety of pathophysiological processes, including oxidative stress, mitophagy, mitochondrial homeostasis, cellular senescence, and cell death. We review the molecular mechanisms underlying the relationship between mitochondrial dysfunction and intervertebral disk degeneration (IDD) to provide a theoretical basis for IDD treatment using pharmacological or tissue-engineering approaches.