Biomarkers of Clinician Burnout.
Biomarkers of Clinician Burnout.
复制标题
临床医生倦怠的生物标志物。
DOI：
10.1007/s11606-021-06757-x
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发表时间：
2022
影响因子：
5.7
通讯作者：
Armstrong,Katrina
中科院分区：
文献类型：
--
作者：
Begin,ArabellaSimpkin;Hata,Susan;Berkowitz,LoriR;Plessow,Franziska;Lawson,ElizabethA;Emptage,Nigel;Armstrong,Katrina
METHODSSalivary and hair cortisol and urinary oxytocin were collected, and perceived burnout (two-item MBI), 5 engagement (Utrecht Work Engagement Scale 6), connection (“I feel a strong sense of connection and community at work”), and trust (“I trust my obgyn colleagues and feel safe discussing concerns with them”) were measured in 25 female clinicians in the ObGyn Department at MGH in May 2018 at the start of a series of monthly support groups designed as part of an ongoing study of strategies to reduce burnout. Hair cortisol concentrations were obtained from the 3 cm most proximal to the scalp reflecting prior three-month cortisol levels. 3 Because of this lag, an additional hair sample was collected three months after initial collection. Linear regression was used to assess the relationship between hormone levels and measures of wellbeing, focusing on association between cortisol and burnout and oxytocin and connection and trust.RESULTSStudy population characteristics, including rates of completion of biomarker assessment, are reported in Table 1. EE was significantly associated with higher salivary cortisol levels (0.03 μg/dL increase with high vs low EE; p= 0.036) whereas DP was significantly associated with lower salivary cortisol levels (0.04 μg/dL decrease with high vs low DP; p= 0.018). When hair cortisol was analyzed as repeated measure, it positively associated with EE (coefficient 20.21, SE8. 77, p= 0.026) and trends toward inverse association with DP (coefficient− 20.18, SE10. 42, p= 0.06). These associations were not significant when adjusting standard errors for clustering within subject (p= 0.19 for both). Oxytocin was significantly higher among participants reporting higher sense of connection (29.2 pg/mg/creatinine (16.2 pg/mg/creatinine) vs 17.3 pg/mg/creatinine (3.8 pg/mg/creatinine); p= 0.028). There was a positive correlation between oxytocin and engagement (r= 0.45; p= 0.048). Oxytocin was higher among participants reporting higher trust in colleagues (29.4 pg/mg/creatinine (19.2 pg/mg/creatinine) vs 19.1 pg/mg/creatinine (4.5 pg/mg/creatinine)), but this did not reach significance (p= 0.076).
