Efficacy of different therapy regimes of low-power laser in painful osteoarthritis of the knee: A double-blind and randomized-controlled trial
Efficacy of different therapy regimes of low-power laser in painful osteoarthritis of the knee: A double-blind and randomized-controlled trial
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DOI：
10.1002/lsm.10236
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发表时间：
2003-01-01
影响因子：
2.4
通讯作者：
Uyar, A
中科院分区：
文献类型：
--
作者：
Gur, A;Cosut, A;Uyar, A
背景和目标：在膝关节骨关节炎（OA）患者中进行了一项前瞻性、双盲、随机和对照试验，以评估红外低功率砷化镓（Ga-As）激光治疗（LPLT）的疗效，并比较两种不同的激光治疗方案。研究设计/材料和方法：90名患者被随机分配到三个治疗组，由一名非治疗作者从90个标有“A”的信封中抽取1个（I组：实际LPLT包括5分钟，3 J总剂量+运动; 30名患者），“B”（II组：实际LPLT包括3分钟，2 J总剂量+运动; 30名患者）和“C”（III组：安慰剂激光组+运动; 30名患者）。所有患者共接受了10次治疗，并在研究期间（14周）继续进行运动治疗计划。在数据分析完成之前，受试者、医生和数据分析员不知道活性或安慰剂激光的代码。在第0、6、10和14周对所有患者的疼痛、主动膝关节屈曲程度、晨僵持续时间、无痛步行距离和持续时间以及西安大略和我硕士大学骨关节炎指数（WOMAC）进行评估。在所有参数方面，如疼痛，功能，两组治疗后生活质量（QoL）指标与治疗前比较有显著性差异（P < 0.01）。结论：LPLT治疗膝骨性关节炎，不同剂量、不同疗程对疗效无影响，两种治疗方案均是安全有效的。(C)2003 Wiley-Liss，Inc.
Background and Objectives: A prospective, double-blind, randomized, and controlled trial was conducted in patients with knee osteoarthritis (OA) to evaluate the efficacy of infrared low-power Gallium-Arsenide (Ga-As) laser therapy (LPLT) and compared two different laser therapy regimes.Study Design/Materials and Methods: Ninety patients were randomly assigned to three treatment groups by one of the nontreating authors by drawing 1 of 90 envelopes labeled 'A' (Group I: actual LPLT consisted of 5 minutes, 3 J total dose + exercise; 30 patients), 'B' (Group II: actual LPLT consisted of 3 minutes, 2 J total dose + exercise; 30 patients), and 'C' (Group III: placebo laser group + exercise; 30 patients). All patients received a total of 10 treatments, and exercise therapy program was continued during study (14 weeks). Subjects, physician, and data analysts were unaware of the code for active or placebo laser until the data analysis was complete. All patients were evaluated with respect to pain, degree of active knee flexion, duration of morning stiffness, painless walking distance and duration, and the Western Ontario and Me Master Universities Osteoarthritis Index (WOMAC) at week 0, 6, 10, and 14.Results: Statistically significant improvements were indicated in respect to all parameters such as pain, function, and quality of life (QoL) measures in the post-therapy period compared to pre-therapy in both active laser groups (P < 0.01). Improvements in all parameters of the Group I and in parameters, such as pain and WOMAC of the Group II, were more statistically significant when compared with placebo laser group (P < 0.05).Conclusions: Our study demonstrated that applications of LPLT in different dose and duration have not affected results and both therapy regimes were a safe and effective method in treatment of knee OA. (C) 2003 Wiley-Liss, Inc.