Vascular Endothelial Growth Factor (VEGF) and the VEGF Soluble Receptor-1 (sFlt-1) in Chorionic Villus Tissue from Chinese Women with Early Recurrent Spontaneous Abortion
Vascular Endothelial Growth Factor (VEGF) and the VEGF Soluble Receptor-1 (sFlt-1) in Chorionic Villus Tissue from Chinese Women with Early Recurrent Spontaneous Abortion
复制标题
中国早期复发性流产妇女绒毛组织中的血管内皮生长因子 (VEGF) 和 VEGF 可溶性受体-1 (sFlt-1)
DOI：
10.1177/147323001103900316
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发表时间：
2011-05-01
影响因子：
1.6
通讯作者：
Shi, L.
中科院分区：
文献类型：
--
作者：
Pang, L-H;Li, M-J;Shi, L.
本病例对照研究探讨了早期复发性自然流产（RSA）与两个基因表达的关系：VEGFA，编码血管内皮生长因子（VEGF）的基因；以及fms相关酪氨酸激酶1 (FLT1)，该基因编码可溶性VEGF受体1 （sFlt-1）。在正常妊娠早期经历RSA或人工流产的妇女被招募到研究中（每组n = 30）。两组间产妇年龄和妊娠期无显著差异。采用定量逆转录-聚合酶链反应检测绒毛膜绒毛组织样品中VEGF和sFlt-1 mRNA的表达水平。RSA患者的绒毛膜绒毛组织中sFlt-1和VEGF mRNA水平显著高于对照组。本研究表明，早期RSA与VEGF和sFlt-1水平存在相关性，提示FLT1和VEGFA基因的过表达可能与RSA的发病机制有关。
This case-control study explored the relationship between early recurrent spontaneous abortion (RSA) and the expression of two genes: VEGFA, the gene encoding vascular endothelial growth factor (VEGF); and fms-related tyrosine kinase 1 (FLT1), the gene encoding the soluble VEGF receptor-1 (sFlt-1). Women experiencing RSA or undergoing induced abortions in the early stage of normal pregnancy were recruited to the study (n = 30 per group). There were no significant between-group differences in maternal age or duration of pregnancy. The levels of VEGF and sFlt-1 mRNA in chorionic villus tissue samples were examined by quantitative reverse transcription-polymerase chain reaction. Levels of sFlt-1 and VEGF mRNA in the chorionic villus tissue of women with RSA were significantly higher than levels in the control group. This study demonstrated that there is a relationship between early RSA and VEGF and sFlt-1 levels, suggesting that over-expression of the FLT1 and VEGFA genes may be associated with the pathogenesis of RSA.