Advances in Development of New Treatment for Leishmaniasis.
Advances in Development of New Treatment for Leishmaniasis.
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DOI：
10.1155/2015/815023
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发表时间：
2015
影响因子：
--
通讯作者：
Veras PS
中科院分区：
文献类型：
--
作者：
de Menezes JP;Guedes CE;Petersen AL;Fraga DB;Veras PS
利什曼病是一种被忽视的传染病，由利什曼原虫属的几种不同种类的原生动物寄生虫引起。目前控制这种疾病的策略主要是基于化疗。尽管在过去的70年里，利什曼原虫化疗缺乏效率，因为它的给药途径是困难的，它可能会导致严重的副作用，这导致耐药病例的出现。医学科学界正面临着用新的合适和有效的药物来克服这些问题以及确定新的药物靶点的困难。利什曼原虫全基因组序列的获得为科学界提供了大规模分析的可能性，这可能会导致更好地了解寄生虫生物学和随后确定新的药物靶点。在这篇综述中，我们专注于如何高通量分析是帮助我们和其他团体，以确定新的目标化疗干预。我们进一步讨论了我们小组最近产生的关于使用高通量技术的数据，以及这如何帮助我们识别和评估新识别目标的潜力。
Leishmaniasis is a neglected infectious disease caused by several different species of protozoan parasites of the genus Leishmania. Current strategies to control this disease are mainly based on chemotherapy. Despite being available for the last 70 years, leishmanial chemotherapy has lack of efficiency, since its route of administration is difficult and it can cause serious side effects, which results in the emergence of resistant cases. The medical-scientific community is facing difficulties to overcome these problems with new suitable and efficient drugs, as well as the identification of new drug targets. The availability of the complete genome sequence of Leishmania has given the scientific community the possibility of large-scale analysis, which may lead to better understanding of parasite biology and consequent identification of novel drug targets. In this review we focus on how high-throughput analysis is helping us and other groups to identify novel targets for chemotherapeutic interventions. We further discuss recent data produced by our group regarding the use of the high-throughput techniques and how this helped us to identify and assess the potential of new identified targets.
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DOI：
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发表时间：
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影响因子：
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