Tempest in a teapot: A systematic review of HPV vaccination and risk compensation research.
Tempest in a teapot: A systematic review of HPV vaccination and risk compensation research.
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DOI：
10.1080/21645515.2016.1141158
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发表时间：
2016-06-02
影响因子：
4.8
通讯作者：
Zimet GD
中科院分区：
文献类型：
--
作者：
Kasting ML;Shapiro GK;Rosberger Z;Kahn JA;Zimet GD
父母和媒体一直担心，为儿童接种人乳头瘤病毒疫苗可能被视为允许儿童从事危险的性行为（也称为性解除抑制）。几项研究发现这种担忧是没有根据的，但没有试图综合相关研究，以评估是否有证据表明性抑制解除。本研究的目的是综合最近的文献，研究性行为和生物学结果（例如，性传播感染）HPV疫苗接种后。我们使用PubMed、CINAHL和Embase检索了2008年1月1日至2015年6月30日期间的文献，检索词如下：[（性行为或性行为或性）和（人乳头瘤病毒或HPV）和（疫苗或疫苗或疫苗接种）]，然后进行引用参考文献检索。我们纳入了研究，检查生物学结果，并报告了男性和女性接种疫苗后的行为。通过标题和摘要对研究进行综述，并将相关研究作为全文文章进行检查。我们确定了2，503篇文章，最终有20篇被纳入综述。没有一项关于性行为和/或生物学结果的研究发现HPV疫苗接种后风险行为或性传播感染率更高的证据。相反，研究发现，与未接种疫苗的人相比，接种疫苗的人不太可能报告不使用避孕套的阴道性交（OR = 0.5; 95%CI = 0.4 - 0.6）和未采取避孕措施（OR = 0.27; 95%CI = 0.15 - 0.48）和未接种疫苗的参与者有较高的衣原体感染率（OR = 2.3; 95%CI = 1.06 - 5.00）。这些结果应该让父母和卫生保健提供者放心。
There has been some concern among parents and in the media that vaccinating children against human papillomavirus could be seen as giving children permission to engage in risky sexual behaviors (also known as sexual disinhibition). Several studies have found this concern to be unfounded but there have been no attempts to synthesize the relevant studies in order to assess if there is evidence of sexual disinhibition. The aim of this study was to synthesize recent literature examining sexual behaviors and biological outcomes (e.g., sexually transmitted infections) post-HPV vaccination. We reviewed literature from January 1, 2008-June 30, 2015 using PubMed, CINAHL, and Embase with the following search terms: [(sex behavior OR sex behavior OR sexual) AND (human papillomavirus OR HPV) AND (vaccines OR vaccine OR vaccination)] followed by a cited reference search. We included studies that examined biological outcomes and reported behaviors post-vaccination in both males and females. Studies were reviewed by title and abstract and relevant studies were examined as full-text articles. We identified 2,503 articles and 20 were eventually included in the review. None of the studies of sexual behaviors and/or biological outcomes found evidence of riskier behaviors or higher rates of STIs after HPV vaccination. Instead, the studies found that vaccinated compared to unvaccinated individuals were less likely to report vaginal intercourse without a condom (OR = 0.5; 95%CI = 0.4–0.6) and non-use of contraception (OR = 0.27; 95%CI = 0.15–0.48) and unvaccinated participants had higher rates of Chlamydia (OR = 2.3; 95%CI = 1.06–5.00). These results should be reassuring to parents and health care providers.