GENETIC-ANALYSIS OF LIFE-SPAN IN CAENORHABDITIS-ELEGANS
GENETIC-ANALYSIS OF LIFE-SPAN IN CAENORHABDITIS-ELEGANS
复制标题
DOI：
10.1073/pnas.79.21.6603
复制
发表时间：
1982-01-01
期刊：
影响因子：
--
通讯作者：
WOOD, WB
中科院分区：
文献类型：
--
作者：
JOHNSON, TE;WOOD, WB
自交两性线虫Bristol和Bergerac品系之间的杂交没有显示出寿命的杂种优势效应，这使得品系间与果蝇或小鼠杂交的分析变得复杂。相反，它们产生的F1后代的寿命与亲本菌株的寿命相似。通过对这些杂交后代F2群体寿命变异的分析，以及对18轮自交F2代重组自交系寿命的2次独立分析，估计线虫寿命的遗传力在20%~50%之间。重组自交系的平均寿命为10-31天，而两个亲本品系的平均寿命约为18天。线虫的寿命变异有很大的遗传成分，这种生物为选择长寿菌株和进行衰老的遗传分析提供了很好的机会。
Crosses between Bristol and Bergerac strains of the self-fertilizing hermaphroditic nematode C. elegans do not show the heterosis effects for life-span that complicate analysis of interstrain crosses with Drosophila or mice. Instead they yield F1 progeny with life-spans similar to those of the parent strains. By analysis of life-span variation among progeny F2 populations from such crosses and by 2 independent analyses of lifespans among recombinant inbred lines derived from F2 individuals by 18 rounds of self-fertilization, the heritability of life-span in C. elegans was estimated between 20% and 50%. Recombinant inbred lines show a range in mean life-spans of 10-31 days compared to life-spans of about 18 days for each of the 2 parental strains. Life-span variation in C. elegans has a substantial genetic component and that this organism offers promising opportunities for selective breeding of longer-lived strains and genetic analysis of senescence.