Preliminary evidence of a decline in perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) concentrations in American Red Cross blood donors
Preliminary evidence of a decline in perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) concentrations in American Red Cross blood donors
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DOI：
10.1016/j.chemosphere.2006.12.031
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发表时间：
2007-05-01
期刊：
影响因子：
8.8
通讯作者：
Zobel, Larry R.
中科院分区：
文献类型：
--
作者：
Olsen, Geary W.;Mair, David C.;Zobel, Larry R.
这项试点研究的目的是确定在全球主要制造商3 M公司于2000-2002年逐步淘汰全氟辛烷磺酰氟（POSF，C8 F17 SO2 F7）材料之后，来自明尼苏达州明尼阿波利斯-圣保罗的美国红十字会献血者体内的全氟辛烷磺酸盐（PFOS，C8 F17 SO 3-）和全氟辛酸盐（PFOA，C7 F15 CO2-）浓度是否有所下降。2005年收集了按年龄和性别分类的40份献血者血浆样本，并将其全氟辛烷磺酸和全氟辛酸浓度与2000年从同一普通人群中收集的100份（非配对）献血者血清样本进行了比较，当时使用四氢全氟辛烷磺酸盐作为内标，采用离子对萃取法对这些样本进行了分析。最初收集的100个样品中的11个用本研究方法重新分析，该方法涉及C-13标记的PFOA加标到供体样品、原始样品、对照人血浆和提取前的校准曲线中，并用作监测提取效率的替代物。通过高效液相色谱串联质谱法进行定量。在分析的100份血清样本中，2000年的全氟辛烷磺酸几何平均值为33.1纳克/毫升（-1）（95%可信区间为29.8-36.7），而2005年40份捐献者血浆样本的几何平均值为15.1纳克/毫升（-1）（95%可信区间为13.3-17.1）（p < 0.0001）。2000年，全氟辛酸的几何平均浓度为4.5 ng/ml（95% CI 4.1-5.0），而2005年为2.2 ng/ml（95% CI 1.9-2.6）（p < 0.0001）。这种下降在供体的年龄和性别之间是一致的。为了证实这些初步的调查结果，将分析2000年抽样的其他子集，并计划对其他地点进行更大规模的生物监测研究。(C)2006爱思唯尔有限公司保留所有权利。
The purpose of this pilot study was to determine whether perfluorooctanesulfonate (PFOS, C8F17SO3-) and perfluorooctanoate (PFOA, C7F15CO2-) concentrations in American Red Cross blood donors from Minneapolis-St. Paul, Minnesota have declined after the 2000-2002 phase-out of perfluorooctanesulfonyl-fluoride (POSF, C8F17SO2F7)-based materials by the primary global manufacturer, 3M Company. Forty donor plasma samples, categorized by age and sex, were collected in 2005, and PFOS and PFOA concentrations were compared to 100 (non-paired) donor serum samples collected in 2000 from the same general population that were analyzed at the time using ion-pair extraction methods with tetrahydroperfluorooctanesulfonate as an internal standard. Eleven of the 100 samples originally collected were reanalyzed with present study methods that involved C-13- labeled PFOA spiked into the donor samples, original samples, control human plasma, and the calibration curve prior to extraction, and was used as a surrogate to monitor extraction efficiency. Quantification was performed by high performance liquid chromatography tandem mass spectrometry methods. Among the 100 serum samples analyzed for PFOS, the geometric mean was 33.1 ng ml(-1) (95% CI 29.8-36.7) in 2000 compared to 15.1 ng ml(-1) (95% CI 13.3-17.1) in 2005 (p < 0.0001) for the 40 donorplasma samples. The geometric mean concentration for PFOA was 4.5 ng ml(-1) (95% CI 4.1-5.0) in 2000 compared to 2.2 ng ml(-1) (95% CI 1.9-2.6) in 2005 (p < 0.0001). The decrease was consistent across donors' age and sex. To confirm these preliminary findings, additional sub-sets of year 2000 samples will be analyzed, and a much larger biomonitoring study of other locations is planned. (C) 2006 Elsevier Ltd. All rights reserved.