Herpes Simplex Virus
Herpes Simplex Virus
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DOI：
10.1007/978-1-4614-8344-1_13
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Rachel A. Gordon;S. Tyring
中科院分区：
文献类型：
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作者：
Rachel A. Gordon;S. Tyring
自从希波克拉底对疾病的早期描述以来，我们对人类单纯疱疹病毒（HSV）的了解已经大大增加[1，2]。值得注意的进展包括疱疹病变与生殖器感染的相关性在十八世纪[3]和维达尔的人传人的认识在1893年[2]。Lipschitz [4]在临床观察中怀疑HSV亚型之间存在抗原差异，1968年得到证实[5]。在现代，有成功的抗病毒治疗可用于大多数HSV感染[6]。对病毒生命周期和基因表达的洞察一直是开发抗病毒治疗（包括新疫苗和基因治疗）的驱动力[4]。
Our understanding of human herpes simplex virus (HSV) has increased tremendously since the early descriptions of disease provided by Hippocrates [1, 2]. Notable advances include the correlation of herpetic lesions with genital infections in the eighteenth century [3] and Vidal’s recognition of human-to-human transmission in 1893 [2]. Antigenic differences between HSV subtypes, suspected on clinical observations by Lipschitz [4], were confirmed in 1968 [5]. In modern day, there is successful antiviral treatment available for most HSV infections [6]. Insight into the viral life cycle and gene expression has been a driving force behind the development of antiviral treatment, including new vaccines and gene therapy [4].