State of hepatitis C viral replication enhances activation of NF-kB- and AP-1-signaling induced by hepatitis B virus X
State of hepatitis C viral replication enhances activation of NF-kB- and AP-1-signaling induced by hepatitis B virus X
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DOI：
10.1016/j.canlet.2005.03.030
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发表时间：
2006-03-28
期刊：
影响因子：
9.7
通讯作者：
Saisho, H
中科院分区：
文献类型：
--
作者：
Kanda, T;Yokosuka, O;Saisho, H
我们检测了X型B肝炎病毒（HBx）对人肝癌细胞系Huh-7（含或不含亚基因组丙型肝炎病毒（HCV）RNA）中NF-κ B和AP-1介导转录的影响。在有HCV的Huh-7细胞中表达HBx导致NF-κ B活化增加4.9倍和AP-1活化增加3.8倍，而在没有HCV的Huh-7细胞中表达HBx导致NF-κ B活化增加2.4倍和AP-1活化增加2.3倍。有趣的是，HCV核心蛋白的成熟形式Core 173的表达在有或没有HCV复制子的Huh 7中均不激活NF-κ B或AP-1转录。HBx蛋白可能在HCV相关性肝癌发生中起重要作用。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
We examined the effect of hepatitis B virus X (HBx) on NF-kB- and AP-1-mediated transcription in human hepatocellular carcinoma cell lines, Huh-7 with or without SUbgenomic hepatitis C virus (HCV) RNA. Expression of HBx in Huh-7 cells with HCV resulted in 4.9 times increased NF-kB-activation and 3.8 times AP-1-activation whereas that without HCV resulted in 2.4 times increased NF-kB-activation and 2.3 times AP-1-activation. Interestingly, the expression of the matured form of HCV core protein, Core 173, did not activate NF-kB- or AP-1-transcription in either Huh7 with or without HCV replicon. HBx protein might play an important role in HCV-related hepatocarcinogenesis. (c) 2005 Elsevier Ireland Ltd. All rights reserved.