Noninvasive Surface Imaging of Breast Cancer in Humans using a Hand-held Optical Imager.
Noninvasive Surface Imaging of Breast Cancer in Humans using a Hand-held Optical Imager.
复制标题
使用手持式光学成像仪对人类乳腺癌进行无创表面成像。
DOI：
10.1088/2057-1976/1/4/045001
复制
发表时间：
2015
影响因子：
1.4
通讯作者：
Godavarty,Anuradha
中科院分区：
文献类型：
--
作者：
Erickson-Bhatt,SarahJ;Roman,Manuela;Gonzalez,Jean;Nunez,Annie;Kiszonas,Richard;Lopez-Penalver,Cristina;Godavarty,Anuradha
X光乳房X光检查是目前检测乳腺癌的黄金标准，其假阴性率为20%(癌症未被发现)，在乳房组织密度较高的年轻女性中，假阴性率会增加。漫反射光学成像是一种安全(非电离)、相对廉价的非侵入性成像方法，可提供人体乳腺癌(包括致密的乳腺组织)的生理信息(如氧合和脱氧血红蛋白浓度)。在光学成像实验室，已经开发出一种手持光学成像仪，该成像仪使用乳房轮廓探头来同时进行大表面的照明和检测，从而接近实时地对人类乳腺癌进行成像。手持式光学成像仪的第一代(Gen-1)和第二代(Gen-2)版本已经开发出来，并先前在组织幻影和健康人体对象中进行了成像。在此，将手持光学成像器应用于乳腺癌受试者的活体成像，以试图确定成像器检测乳腺肿瘤的能力。五名女性受试者(年龄51-74岁)被诊断为乳腺癌，在手术干预前用GEN-1光学成像仪进行成像。其中一名受试者还用GEN-2光学成像仪进行了成像。这两种成像仪都使用785 nm激光二极管光源和增强型电荷耦合器件摄像探测器来生成总血红蛋白吸收的2D表面图。受试者仰卧，在同侧(含肿瘤)和对侧(非含肿瘤)乳房的不同位置采集图像。光学图像(由于总血红蛋白浓度而产生的光学吸收的2D表面图)显示肿瘤部位的高强度区域，这表明由于肿瘤的存在，血管增加和血液含量增加。此外，初步结果表明有可能对淋巴扩散进行成像。这项研究证明了手持光学设备对人体乳腺癌进行非侵入性成像的潜力。
X-ray mammography, the current gold standard for breast cancer detection, has a 20% false-negative rate (cancer is undetected) and increases in younger women with denser breast tissue. Diffuse optical imaging is a safe (nonionizing), and relatively inexpensive method for noninvasive imaging of breast cancer in human subjects (including dense breast tissues) by providing physiological information (eg oxy-and deoxy-hemoglobin concentration). At the Optical Imaging Laboratory, a hand-held optical imager has been developed which employs a breast contourable probe head to perform simultaneous illumination and detection of large surfaces towards near real-time imaging of human breast cancer. First generation (gen-1) and second generation (gen-2) versions of the hand-held optical imager have been developed and previously demonstrated imaging in tissue phantoms and healthy human subjects. Herein, the hand-held optical imagers are applied towards in vivo imaging of breast cancer subjects in an attempt to determine the ability of the imager to detect breast tumors. Five female human subjects (ages 51–74) diagnosed with breast cancer were imaged with the gen-1 optical imager prior to surgical intervention. One of the subjects was also imaged with the gen-2 optical imager. Both imagers use 785 nm laser diode sources and intensified charge-coupled device camera detectors to generate 2D surface maps of total hemoglobin absorption. The subjects lay in supine position and images were collected at various locations on both the ipsilateral (tumor-containing) and contralateral (non-tumor containing) breasts. The optical images (2D surface maps of optical absorption due to total hemoglobin concentration) show regions of higher intensity at the tumor location, which is indicative of increased vasculature and higher blood content due to the presence of the tumor. Additionally, a preliminary result indicates the potential to image lymphatic spread. This study demonstrates the potential of the hand-held optical devices to noninvasively image breast cancer in human subjects.