Ultra-sensitive SQUID instrumentation for MEG and NCI by ULF MRI

Ultra-sensitive SQUID instrumentation for MEG and NCI by ULF MRI
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用于 MEG 和 NCI 的 ULF MRI 超灵敏 SQUID 仪器

DOI:
10.1007/978-981-10-5122-7_199
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发表时间:
2018
期刊:
arXiv: Instrumentation and Detectors
影响因子:
--
通讯作者:
R. Körber
R. Körber
中科院分区:
--
文献类型:
--
作者:
R. Körber

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提出了用于生物磁学的超灵敏SQUID仪器的构造要求。通常,SQUID被电感耦合到拾取线圈,对于这种布置,可以通过增加传感线圈面积来改善噪声性能。为了获得最佳的灵敏度,必须考虑信噪比(SNR),它是源特性和噪声源之间复杂的相互作用。事实证明,对于不同的噪声特性,即使对于相同的源,也需要单独的拾取线圈设计。因此,具有不同大小的拾取线圈的混合系统是多用途应用的最佳选择。还描述了一种接近SQUID本征噪声电平的单通道系统。这可以通过使用特殊的杜瓦设计来实现,从而能够进一步提高信噪比。这样的系统可用于电流密度成像和超低场磁共振神经元电流成像,其中还必须能够耐场高达100-200mT。
The requirements for the construction of ultra-sensitive SQUID instrumentation as used in biomagnetism are presented. Typically, SQUIDs are inductively coupled to pick-up coils and for this arrangement one can improve the noise performance by increasing the sensing coil area. To achieve optimum sensitivity one has to consider the signal-to-noise ratio (SNR), which is an intricate interplay between source characteristics and noise origin. It turns out that separate pick-up coil designs are needed for various noise characteristics even for an identical source. Hence, a hybrid system with differently sized pick-up coils presents the best option for multipurpose applications. A single channel system with close to SQUID intrinsic noise level is also described. This is possible by utilizing a special dewar design and thereby enabling a further increase in SNR. Such a system might be used for current density imaging and neuronal current imaging by ultra-low-field magnetic resonance where it also must be able to be field-tolerant to up to 100-200 mT.
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