Mild cognitive impairment: prevalence and predictive validity according to current approaches
Mild cognitive impairment: prevalence and predictive validity according to current approaches
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DOI：
10.1034/j.1600-0404.2003.00118.x
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发表时间：
2003-08-01
影响因子：
3.5
通讯作者：
Angermeyer, MC
中科院分区：
文献类型：
--
作者：
Busse, A;Bischkopf, J;Angermeyer, MC
目的-轻度认知功能障碍与痴呆症发病风险增加有关。然而，在诊断标准上没有共识，并且很少在基于人群的样本中评估不同的概念。本文比较了在一项基于人群的研究中不同概念的患病率和预测效度。其目的是确定一个概念的最佳关系的灵敏度和特异性在预测痴呆症。材料和方法-一个社区样本的1045名老年痴呆症患者年龄在75岁及以上的神经心理学测试进行了检查，在三波纵向研究。根据所采用的概念，患病率从3%到36%不等。在2.6年内，痴呆症的转化率为23%至47%。此外，受试者工作特征曲线表明，除了一个轻度认知障碍的概念可以预测痴呆症。结论：轻度认知功能障碍在老年人中非常常见。患病率和预测有效性高度依赖于所应用的诊断标准。
Objectives - Mild cognitive impairment is associated with an increased risk of developing dementia. However, there is no consensus on diagnostic criteria and different concepts have rarely been evaluated in population-based samples. This paper compares the prevalences and predictive validities for different concepts in a population-based study. The aim was to identify a concept with the best relation of sensitivity and specificity in the prediction of dementia. Material and methods - A community sample of 1045 dementia-free individuals aged 75 years and over was examined by neuropsychological testing in a three-wave longitudinal study. Prevalence rates ranged from 3 to 36% according to the concept applied. Conversion rates to dementia over 2.6 years ranged from 23 to 47%. In addition, receiver operating characteristic curves indicated that all but one concept for mild cognitive impairment could predict dementia. Conclusion - Mild cognitive impairment is very frequent in older people. Prevalences and predictive validities are highly dependent on the diagnostic criteria applied.