Separation and characterization of a subset of human T8+ cells which function as antigen-presenting and contrasuppressor cells.
Separation and characterization of a subset of human T8+ cells which function as antigen-presenting and contrasuppressor cells.
复制标题
人类 T8 细胞子集的分离和表征，这些细胞充当抗原呈递细胞和反抑制细胞。
作者：
T. Lehner;J. Avery;T. Jones
Vicia villosa（VV）凝集素优先结合T细胞亚群。分离的VV-粘附细胞（AC）不单独产生辅助功能，但当加入VV-非粘附细胞（NAC）时，它们可以呈递链球菌抗原（SA），并以1 VV-AC：4 VV-NAC的比例与单核细胞一样有效地诱导辅助功能。进一步分离成VV-AC的T8+亚群并用T4+辅助细胞（HC）重建已经确定T8+ VV-AC诱导T4+细胞具有辅助活性。然而，除了抗原呈递之外，VV-AC的T8+亚群还具有反抑制功能，因为它可以阻止T8+抑制细胞抑制T4+ HC功能。结果表明，T8+亚群可以将抗原呈递给T4+ HC，激活辅助功能并防止抑制。T8+ VV-AC具有对抗显性抑制活性和提呈抗原诱导辅助活性的双重功能，可能具有相当大的生物学意义。
The lectin Vicia villosa (VV) binds preferentially a subset of T cells. Separated VV-adherent cells (AC) do not generate helper function alone, but when added to VV-non-adherent cells (NAC), they can present streptococcal antigen (SA) and induce helper function as effectively as monocytes, at a ratio of 1 VV-AC to 4 VV-NAC. Further separation into a T8+ subset of VV-AC and reconstitution with T4+ helper cells (HC) has established that the T8+ VV-AC induces T4+ cells to helper activity. However, in addition to antigen presentation, the T8+ subset of VV-AC has a contrasuppressor function, for it can prevent T8+ suppressor cells from inhibiting T4+ HC function. The results suggest that a T8+ subset can present antigen to T4+ HC, activate helper function and prevent suppression. The T8+ VV-AC may have considerable biological significance in its dual function of countering the dominant suppressor activity and presenting antigen to induce helper activity.