Genetic polymorphism investigation of 16 X-STR loci in the Bai ethnic minority in Yunnan Province, Southwest China
Genetic polymorphism investigation of 16 X-STR loci in the Bai ethnic minority in Yunnan Province, Southwest China
复制标题
云南白族16个X-STR位点遗传多态性调查
DOI：
10.1007/s00414-020-02454-2
复制
发表时间：
2020-11-12
影响因子：
2.1
通讯作者：
Hu, Liping
中科院分区：
文献类型：
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作者：
Qing, Lili;Li, Yi;Hu, Liping
为了研究白族16个x染色体短串重复（X-STR）基因座（DX6795、DXS9902、DXS8378、HPRTB、GATA165B12、DXS7132、DXS7424、DXS6807、DXS6803、GATA172D05、DXS6800、DXS10134、GATA31E08、DXS10159、DXS6789和DXS6810）在云南大理白族自治州无亲缘关系的健康白族424例（男性202例，女性222例）的等位基因频率、法医学参数和单倍型频率，探讨了这些基因座的遗传变异和法医学效率。中国。共观察到132个等位基因；每个位点检测到5 ~ 19个等位基因，等位基因频率在0.0016 ~ 0.7589之间。除DXS6800位点外，其余位点在云南白族人群中均呈高度多态性。雌性和雄性的综合歧视力分别为0.99999999999999996和0.999999997487061。根据系统发育树，同一地区的邻近种群和不同民族似乎具有相对密切的进化关系。本研究为云南白族提供并补充了x染色体遗传多态性数据，丰富了这一中国少数民族人群的参考资料。
To investigate the genetic variation and forensic efficiency of 16 X-chromosomal short tandem repeat (X-STR) loci (DX6795, DXS9902, DXS8378, HPRTB, GATA165B12, DXS7132, DXS7424, DXS6807, DXS6803, GATA172D05, DXS6800, DXS10134, GATA31E08, DXS10159, DXS6789, and DXS6810) in the Bai minority, we calculated allele frequencies, forensic parameters, and haplotype frequencies in 424 (202 males and 222 females) unrelated, healthy Bai individuals from Dali Bai Autonomous Prefecture in Yunnan Province, China. We observed a total of 132 alleles; 5–19 alleles were detected in each locus, and the corresponding allele frequencies ranged from 0.0016 to 0.7589. All of the loci detected were highly polymorphic in the Bai population in Yunnan Province, except DXS6800. The values for the combined power of discrimination in females (PDf) and males (PDm) were 0.999999999999996 and 0.999999997487061, respectively. According to a phylogenetic tree, neighboring populations and different nationalities in the same area appeared to have relatively close evolutionary relationships. This study provides and complements X-chromosome genetic polymorphism data for the Bai people in Yunnan Province, Southwest China, and enriches the available reference materials for this Chinese minority population.