Impact of Glucose Tolerance Status on Development of Ischemic Stroke and Coronary Heart Disease in a General Japanese Population The Hisayama Study
Impact of Glucose Tolerance Status on Development of Ischemic Stroke and Coronary Heart Disease in a General Japanese Population The Hisayama Study
复制标题
DOI：
10.1161/strokeaha.109.564708
复制
发表时间：
2010-02-01
期刊：
影响因子：
8.3
通讯作者：
Kiyohara, Yutaka
中科院分区：
文献类型：
--
作者：
Doi, Yasufumi;Ninomiya, Toshiharu;Kiyohara, Yutaka
背景和目的--很少有研究表明75克口服葡萄糖耐量试验定义的葡萄糖耐量状态与不同类型心血管疾病的发生之间存在关联。方法--对2421名年龄在40至79岁之间的日本社区居民进行了为期14年的口服葡萄糖耐量试验。结果--在多变量分析中，根据世界卫生组织的标准，糖尿病患者的男女缺血性卒中和女性冠心病（CHD）的风险显著高于糖耐量正常者，即使调整了其他混杂因素，但男性CHD中未观察到这种相关性（缺血性卒中：男性校正的风险比[HR] = 2.54，P = 0.002;女性校正的HR = 2.02，P = 0.03; CHD：男性校正的HR = 1.26，P = 0.47;女性校正的HR = 3.46，P = 0.002）。空腹血糖水平≥ 7.0 mmol/L时也观察到类似的相关性（缺血性卒中：男性校正HR = 2.15，P = 0.03;女性校正HR = 2.10，P = 0.045;冠心病：男性校正HR = 1.29，P = 0.47;女性校正HR = 3.83，P = 0.003）和2小时负荷后血糖水平>= 11.1 mmol/L（缺血性卒中：男性校正HR = 2.71，P = 0.003;女性校正HR = 2.19，P = 0.03;冠心病：男性校正HR = 1.58，P = 0.16;女性校正HR = 4.44，P < 0.001）。年龄调整后的缺血性中风和冠心病的发病率并没有显着增加空腹血糖受损或糖耐量受损的受试者在either sex. Conclusions，我们的研究结果表明，糖尿病是一个独立的危险因素，缺血性中风的性别和女性冠心病在日本人口。（中风。2010; 41：203-209）。
Background and Purpose-Few studies have shown the association between glucose tolerance status defined by a 75-g oral glucose tolerance test and the development of different types of cardiovascular disease.Methods-A total of 2421 community-dwelling Japanese subjects aged 40 to 79 years who underwent the oral glucose tolerance test were followed up for 14 years.Results-In multivariable analysis, the risks of ischemic stroke in both sexes and coronary heart disease (CHD) in women were significantly higher in subjects with diabetes determined by the World Health Organization criteria than in those with normal glucose tolerance even after adjustment for other confounding factors, but such association was not seen for CHD in men (ischemic stroke: adjusted hazard ratio [HR] = 2.54, P = 0.002 in men; adjusted HR = 2.02, P = 0.03 in women; CHD: adjusted HR = 1.26, P = 0.47 in men; adjusted HR = 3.46, P = 0.002 in women). Similar associations were observed for fasting plasma glucose levels of >= 7.0 mmol/L (ischemic stroke: adjusted HR = 2.15, P = 0.03 in men; adjusted HR = 2.10, P = 0.045 in women; CHD: adjusted HR = 1.29, P = 0.47 in men; adjusted HR = 3.83, P = 0.003 in women) and for 2-hour postload glucose levels of >= 11.1 mmol/L (ischemic stroke: adjusted HR = 2.71, P = 0.003 in men; adjusted HR = 2.19, P = 0.03 in women; CHD: adjusted HR = 1.58, P = 0.16 in men; adjusted HR = 4.44, P < 0.001 in women). The age-adjusted incidences of ischemic stroke and CHD did not significantly increase in subjects with impaired fasting glycemia or impaired glucose tolerance in either sex.Conclusions-Our findings suggest that diabetes is an independent risk factor for ischemic stroke in both sexes and CHD in women in the Japanese population. (Stroke. 2010; 41: 203-209.)