Prophylactic use of midazolam or propofol at the end of surgery may reduce the incidence of emergence agitation after sevoflurane anaesthesia
Prophylactic use of midazolam or propofol at the end of surgery may reduce the incidence of emergence agitation after sevoflurane anaesthesia
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DOI：
10.1177/0310057x1103900516
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发表时间：
2011-09-01
影响因子：
1.5
通讯作者：
Yoon, S. M.
中科院分区：
文献类型：
--
作者：
Kim, Y. H.;Yoon, S. Z.;Yoon, S. M.
七氟烷与儿童中出现激越的高发生率相关。已对咪达唑仑和丙泊酚进行了检查，目的是减少七氟烷麻醉后的苏醒期躁动。然而，这两种药物对出现躁动的影响仍然存在争议。因此，我们设计了这项研究，以衡量咪达唑仑或丙泊酚在手术结束后对恢复期的苏醒期躁动的影响。101名儿童，年龄1至13岁，接受斜视手术，参加了这项随机双盲研究。在N（2）O/O（2）中用七氟烷诱导和维持麻醉。随机分为咪唑安定0.05 mg/kg组（M组，n=35）、异丙酚1 mg/kg组（P组，n=31）和生理盐水组（S组，n=35）。苏醒期躁动发生率M组为42.9%（15/35），P组为48.4%（15/31），S组为74.3%（26/35）。M组和P组苏醒期躁动发生率明显低于S组。与S组相比，M组和P组患者的苏醒时间延长。P组和M组之间的苏醒期躁动发生率或苏醒时间无显著差异。我们得出结论，手术结束前给予丙泊酚或咪达唑仑可有效降低在七氟烷麻醉下接受斜视手术的儿童的苏醒期躁动发生率。
Sevoflurane is associated with a high incidence of emergence agitation in children. Midazolam and propofol have been examined with the aim of reducing emergence agitation after sevoflurane anaesthesia. However; the effect of both drugs on emergence agitation is still controversial. Therefore we designed this study to measure the effect of midazolam or propofol at the end of surgery on emergence agitation during the recovery period.One hundred and one children, aged one to 13 years, undergoing strabismus surgery were enrolled in this randomised double-blind study. Anaesthesia was induced and maintained with sevoflurane in N(2)O/O(2). Children were randomly assigned to receive midazolam 0.05 mg/kg (group M, n=35), propofol 1 mg/kg (group P, n=31) or saline (group S, n=35). A four-point scale was used to evaluate recovery characteristics upon awakening and during the first hour after emergence from anaesthesia.The incidence of emergence agitation in group M was 42.9% (15/35), in group P 48.4% (15/31) and in group S 74.3% (26/35). The incidence of emergence agitation in groups M and P was significantly less than in group S. The emergence time was prolonged for patients in groups M and P compared to group S. There was no significant difference in the incidence of emergence agitation or in emergence times between the groups P and M.We conclude that propofol or midazolam administration before the end of surgery may be effective in reducing the incidence of emergence agitation in children undergoing strabismus surgery under sevoflurane anaesthesia.