Anatomical correlates of quality of life: Evidence from voxel‐based morphometry
Anatomical correlates of quality of life: Evidence from voxel‐based morphometry
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DOI：
10.1002/hbm.22294
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发表时间：
2014-05
影响因子：
4.8
通讯作者：
H. Takeuchi;Y. Taki;R. Nouchi;H. Hashizume;Y. Sassa;A. Sekiguchi;Yuka Kotozaki;Seishu Nakagawa;T. Nagase;C. Miyauchi;R. Kawashima
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作者：
H. Takeuchi;Y. Taki;R. Nouchi;H. Hashizume;Y. Sassa;A. Sekiguchi;Yuka Kotozaki;Seishu Nakagawa;T. Nagase;C. Miyauchi;R. Kawashima
生活质量（QOL）有多种定义，这些定义通常强调幸福和对生活的满意度。已知与健康相关的问题会导致较低的生活质量。然而，问卷测量的健康青年生活质量个体差异的神经机制尚不清楚。生活质量对我们的健康至关重要，对未妥协受试者生活质量的神经机制的研究显然具有重大的科学和社会意义。我们使用基于体素的形态计量学研究了人类健康青年（年龄21.4±1.8岁）男性（n = 88）和女性（n = 68）大脑区域灰质体积（rGMV）和QOLMQ之间的关系。我们发现，QOLMQ和rGMV在左前额叶皮层的一个区域、扣带回前背部分和偶然扣带回区域呈显著负相关。这些发现表明，与处理负面情绪（如恐惧和愤怒）相关的区域以及与评估内部产生的信息相关的区域的结构变化与QOLMQ有关。这些发现表明，这些过程可能与健康年轻人的QOLMQ有关。脑科学学报（英文版），2014。©2013 Wiley期刊公司
Quality of life (QOL) has been defined in many ways, and these definitions usually emphasize happiness and satisfaction with life. Health‐related problems are known to cause lower QOL. However, the neural mechanisms underlying individual differences in QOL measured by questionnaire (QOLMQ) in young healthy subjects are unknown. QOL is essential to our well‐being, and investigation of the neural mechanisms underlying QOL in uncompromised subjects is obviously of great scientific and social interest. We used voxel‐based morphometry to investigate the association between regional gray matter volume (rGMV) and QOLMQ across the brain in healthy young adults (age, 21.4 ± 1.8 years) men (n = 88) and women (n = 68) in humans. We found significant negative relationships between QOLMQ and rGMV in a region in the left rostrolateral prefrontal cortex and regions in the dorsal part of the anterior cingulate gyrus and contingent cingulate regions. These findings show that structural variations in regions associated with processing of negative emotions such as fear and anger as well as those associated with evaluation of internally generated information are associated with QOLMQ. These findings suggest that these processes might be related to QOLMQ in healthy young adults. Hum Brain Mapp 35:1834–1846, 2014. © 2013 Wiley Periodicals, Inc.