Efforts to enhance safety measures for CRISPR/Cas-based gene drive technology in Japan
Efforts to enhance safety measures for CRISPR/Cas-based gene drive technology in Japan
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日本努力加强基于 CRISPR/Cas 的基因驱动技术的安全措施
DOI：
10.11162/daikankyo.e19sc0801
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Takumi Nishiuchi
中科院分区：
文献类型：
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作者：
Toshinori Tanaka;Nobukazu Tanaka;Yukio Nagano;Hirotaka Kanuka;Daisuke S Yamamoto;Natsuko Yamamoto;Eiji Nanba;Takumi Nishiuchi
在日本，为了降低CCGDT带来的风险，在遗传研究促进学术协会（AAPGS）成立了基因驱动工作组，并经过工作组的全面和广泛的讨论，向日本包括研究机构在内的公众发布了《基因驱动处理声明》。开展了全国CCGDT调查。调查结果显示，重组DNA机构审查委员会委员和秘书处、生物安全官等管理人员对CCGDT有一定的认识，并利用重组DNA实验申请表，努力掌握与CCGDT相关的实验计划。相比之下，CCGDT的潜在风险并没有被许多研究者所了解。所有利益相关者都需要向所有可能希望使用该技术的研究人员传播CCGDT的潜在风险和预防措施。研究人员在充分了解CCGDT的潜在风险并采取必要措施的前提下使用CCGDT。本报告是基于2018年亚洲实验室安全与教育会议的海报展示，讨论了基于CRISPR/ cas的基因驱动技术对生态系统的潜在风险的安全措施，以及日本全国范围内基因驱动问卷调查的结果。
In Japan, a Working Group on Gene Drive has been established in the Academic Association for Promotion of Genetic Studies (AAPGS), and a Statement on the Handling of Gene Drive was issued to the public including research institute across Japan, after comprehensive and extensive discussions by the working group in order to reduce risks posed by CCGDT. A national-wide survey on CCGDT was implemented. The survey revealed that those in managerial positions including members and secretariats of institutional review boards on recombinant DNA, and biosafety officers are conscious of CCGDT, and efforts to grasp experimental plans involving CCGDT are made by utilizing an application form for recombinant DNA experiment. In contrast, potential risks of CCGDT are not understood by many researchers. All stakeholders need to disseminate potential risks and preventive measures regarding CCGDT to all researchers who may wish to use this technology. Researchers should use CCGDT upon understanding its potential risks and taking necessary measures. This report refers to how safety measures for CRISPR/Cas-based gene drive technology which has potential risks to ecological system has been discussed and results of national-wide questionnaire survey on gene drive in Japan based on the poster presentation at the Asian Conference on Safety & Education in Laboratory 2018.