Elevated Brain-Derived Neurotrophic Factor Correlates Negatively with Severity and Duration of Major Depressive Episodes
Elevated Brain-Derived Neurotrophic Factor Correlates Negatively with Severity and Duration of Major Depressive Episodes
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DOI：
10.1097/wnn.0000000000000089
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发表时间：
2016-03-01
影响因子：
1.4
通讯作者：
Dana-Alamdari, Leyli
中科院分区：
文献类型：
--
作者：
Kheirouri, Sorayya;Noorazar, Seyed Gholamreza;Dana-Alamdari, Leyli
背景和目的：重度抑郁症是一种神经精神疾病，与神经化学变化有关，改变神经营养因子的水平。我们的目的是测量血清脑源性神经营养因子（BDNF）和神经生长因子（NGF）的患者经历了他们的第一次发作的抑郁症，并检查这些水平的严重程度和抑郁发作的持续时间。方法：我们招募了85名参与者：44名无药物的抑郁症患者（35名女性，9名男性）和41名健康对照（32名女性，9名男性）。我们使用汉密尔顿抑郁量表评估患者抑郁的严重程度。对照组的心理健康状况按《精神疾病诊断与统计手册》第4艾德版进行评定。为了评估所有参与者的压力水平，我们使用了Holmes和Rahe压力量表。结果：患者的平均应激评分明显高于对照组（P=0.03）。患者血清BDNF水平高于对照组（P=0.001），但NGF水平相似。BDNF水平与症状严重程度（r=-0.33，P =0.03）和病程（r=-0.2，P =0.06）呈负相关。NGF水平与压力或抑郁发作的严重程度或持续时间没有相关性。结论：这些研究结果表明，血清BDNF水平升高可能有助于重度抑郁症的病理生理。研究结果还表明BDNF在改变病情的临床过程中可能起作用。
Background and Objective: Major depressive disorder is a neuropsychiatric condition associated with neurochemical changes that alter levels of neurotrophins. We aimed to measure serum levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in patients experiencing their first episode of major depression and to examine those levels in relation to the severity and duration of the depressive episode.Methods: We recruited 85 participants: 44 drug-free patients with major depression (35 women, 9 men) and 41 healthy controls (32 women, 9 men). We used the Hamilton Rating Scale for Depression to assess the severity of the patients' depression. We assessed the controls' mental health according to Diagnostic and Statistical Manual of Mental Disorders, 4th ed, criteria. To assess all participants' stress levels, we used the Holmes and Rahe stress scale. We measured all participants' serum BDNF and NGF levels via enzyme-linked immunosorbent assay.Results: The mean stress score was significantly higher in the patients than the controls (P=0.03). The patients had higher serum BDNF than the controls (P=0.001), but similar NGF levels. BDNF levels correlated negatively with symptom severity (r=-0.33, P=0.03) and duration (r=-0.2, P=0.06). NGF levels did not correlate with stress or with severity or duration of depressive episode.Conclusions: These findings suggest that an elevated serum BDNF level may contribute to the pathophysiology of major depressive disorder. The findings also indicate a possible role for BDNF in altering the clinical course of the condition.