Health-related quality of life in pediatric liver transplant recipients: A single-center study
Health-related quality of life in pediatric liver transplant recipients: A single-center study
复制标题
DOI：
10.1053/jlts.2003.50012
复制
发表时间：
2003-01-01
影响因子：
4.6
通讯作者：
Kotagal, U
中科院分区：
文献类型：
--
作者：
Bucuvalas, JC;Britto, M;Kotagal, U
本研究的目的是(1)测量儿童肝移植(LT)的健康相关生活质量(HRQOL)，(2)确定与HRQOL相关的人口学和临床因素，(3)比较两种用于测量儿童和青少年HRQOL的工具。我们开展了一项单中心横断面研究，研究对象为77名年龄在5至18岁之间的接受同种异体肝移植的儿童，他们都曾接受过至少6个月的同种异体肝移植。我们使用儿童健康问卷父母表50(CHQPF50)和PedsQL4.0从父母的角度确定测量的身心健康维度。个人量表的得分从0到100不等，得分越高表明健康状况越好。收集人口统计学、移植时的临床状态、移植后的临床病程和移植物功能的数据，以确定移植后HRQOL的预测因素。53%的肝移植受者有胆道闭锁，78%是白人，61%是女性。术后平均年龄3.8+/-3.6岁，术后1~15年。儿童肝移植受者的HRQOL低于报道的健康儿童，但与其他慢性病儿童相似。移植时的年龄、移植后经过的时间、前一年内的住院时间、母亲的教育程度和种族是身体健康的重要预测因素。移植时的年龄和母亲的教育可以预测心理社会功能。与一般人群相比，儿童肝移植受者的HRQOL降低，与患有慢性病的儿童相似。前瞻性纵向研究将使我们能够确定移植后不同时期的HRQOL的预测因素。从这项研究中获得的信息将帮助我们更好地确定患者及其家属对肝移植后的期望和临床过程。
The goals of the present study were (1) to measure health-related quality of life (HRQOL) in pediatric liver transplantation (LT), (2) to identify demographic and clinical factors that correlate with HRQOL, and (3) to compare two instruments that have been used to measure HRQOL in children and adolescents. We conducted a single-center cross-sectional study of 77 pediatric LT recipients ages 5 to 18 years, all of whom had had LT at least 6 months previously. We used the Child Health Questionnaire Parent Form 50 (CHQPF50) and the PedsQL4.0 to determine measured dimensions of physical and psychosocial health from the parents' perspective. Individual scale scores range from 0 to 100, with higher scores reflecting better health. Data on demographics, clinical status at transplantation, posttransplantation clinical course, and graft function were collected to identify predictors of posttransplantation HRQOL. Fifty-three percent of the liver transplant recipients had biliary atresia, 78% were white, and 61% were female. The mean age at LT was 3.8 +/- 3.6 years, and the range of time since LT was I to 15 years. HRQOL in pediatric liver transplant recipients was lower than that reported for healthy children but similar to that for children with other chronic illness. Age at transplantation, the time elapsed since transplantation, hospitalizations within the previous year, maternal education, and race were significant predictors of physical health. Age at transplantation and maternal education predicted psychosocial function. HRQOL was decreased in a population of pediatric liver transplant recipients compared with the general population and similar to that for children with chronic illness. Prospective longitudinal studies will permit us to define predictors of HRQOL at different periods of time after transplantation. The information gained from this study will help us to better define expectations and the clinical course after liver transplantation to patients and their families.