Prognostic role of neutrophil-to-lymphocyte ratio in aortic disease: a meta-analysis of observational studies
Prognostic role of neutrophil-to-lymphocyte ratio in aortic disease: a meta-analysis of observational studies
复制标题
中性粒细胞与淋巴细胞比率在主动脉疾病中的预后作用：观察性研究的荟萃分析
DOI：
10.1186/s13019-020-01263-3
复制
发表时间：
2020-08-10
影响因子：
1.6
通讯作者：
Cheng, Xiaoshu
中科院分区：
文献类型：
--
作者：
Xu, Yan;Fang, Haiyang;Cheng, Xiaoshu
ObjectiveRecent studies have reported that neutrophil-to-lymphocyte ratio (NLR) is associated with cardiovascular disease. The aim of the present study was to investigate the prognostic value of NLR in aortic disease.MethodsWe systematically searched electronic databases (Cochrane, PubMed, Elsevier, Medline, and Embase) from their inception to March 2020. Observational studies that evaluated the relationship between NLR and aortic disease were eligible for critical appraisal. Data were extracted from applicable articles, risk ratio (RR), weighted mean differences (MD) and 95% confidence intervals (CI) were calculated by RevMan 5.3, and statistical heterogeneity was assessed by the I2statistic.ResultsFourteen studies enrolling 4066 individuals were included in the meta-analysis. Compared with the control group, NLR was significantly higher in the aortic disease group (MD 3.44, 95%CI: 0.81–6.07,P= 0.01, I2= 99%). The NLR was also significantly higher in non-survivors with aortic disease, compared to the survivors (MD 4.62, 95%CI: 2.75–6.50,P< 0.00001, I2= 60%). Compared with the aortic disease patients with a low NLR, mortality was significantly higher in those with a high NLR (RR 2.63, 95%CI: 1.79–3.86,P< 0.00001, I2= 67%).ConclusionBased on current evidence, an elevated NLR was associated with aortic disease and in-hospital mortality. Raised NLR also demonstrated a significantly increased the risk of mortality after surgical repair in aortic disease patients. NLR may be a good prognostic biomarker in aortic disease and deserve further research in this area.
