Lack association of body mass index with disease activity composites of rheumatoid arthritis in Korean population: cross-sectional observation
Lack association of body mass index with disease activity composites of rheumatoid arthritis in Korean population: cross-sectional observation
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DOI：
10.1007/s10067-013-2427-8
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发表时间：
2014-04-01
影响因子：
3.4
通讯作者：
Kim, Seong-Kyu
中科院分区：
文献类型：
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作者：
Choe, Jung-Yoon;Bae, Jisuk;Kim, Seong-Kyu
关于体重指数（BMI）对类风湿性关节炎（RA）临床疾病活动性影响的争论仍未解决。本研究调查了韩国RA患者的BMI是否与疾病活动复合物和临床参数相关。共有568例RA患者连续入组本研究。评估BMI和疾病活动性复合物，包括疾病活动性评分28（DAS 28）和临床/简化疾病活动性指数（CDAI/SDAI）。采用卡方检验、单因素方差分析和多变量回归分析进行统计学分析。RA疾病活动的缓解定义为DAS 28评分中千分之2.6。平均BMI为22.3 kg/m2（SD 3.1）。约60.6%（n = 344）的入组患者属于体重过轻和正常BMI类别。Swedish关节计数在四种BMI类别之间存在显著差异（p = 0.038）。多元回归分析显示所有患者的BMI和红细胞沉降率（ESR）呈负相关（β = -aEuro千分之0.011，p = 0.049），还发现其他疾病活动指数与BMI无关。在缓解患者中，较低的BMI与较高的医生总体估计值相关（β = -aEuro千分之0.446，p = 0.030）。未缓解组中BMI和ESR之间存在负相关（β = -aEuro千分之0.016，p = 0.019）。这项研究显示，尽管在RA患者中仅发现ESR与BMI相关，但BMI与RA的疾病活动性复合物之间缺乏相关性。
The debate regarding the influence of body mass index (BMI) on clinical disease activity in rheumatoid arthritis (RA) remains unsolved. This study investigates whether BMI is associated with disease activity composites and clinical parameters in Korean patients with RA. A total of 568 patients with RA were consecutively enrolled in this study. BMI and disease activity composites including the Disease Activity Score 28 (DAS28) and the Clinical/Simplified Disease Activity Index (CDAI/SDAI) were assessed. Statistical analyses were performed using Chi-square, one-way ANOVA, and multivariate regression analyses. Remission of RA disease activity was defined as a parts per thousand currency sign2.6 in a DAS28 score. The mean BMI was 22.3 kg/m(2) (SD 3.1). About 60.6 % (n = 344) of enrolled patients fell into the underweight and normal BMI categories. Swollen joint count was significantly different among the four BMI categories (p = 0.038). Multivariate regression analysis showed a negative correlation of BMI and erythrocyte sediment rate (ESR) in all patients (beta= -aEuro parts per thousand 0.011, p = 0.049) and also found that other disease activity indices were not found to be associated with BMI. In patients with remission, lower BMI was associated with higher physician global estimate (beta= -aEuro parts per thousand 0.446, p = 0.030). The negative association between BMI and ESR in the non-remission group was noted (beta= -aEuro parts per thousand 0.016, p = 0.019). This study revealed lack association between BMI and disease activity composites of RA, although only ESR was found to be associated with BMI in RA patients.