Serum leptin and somatotropin components correlate with neonatal birth weight
Serum leptin and somatotropin components correlate with neonatal birth weight
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DOI：
10.1159/000052983
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发表时间：
2001-01-01
影响因子：
2.1
通讯作者：
Basurto, L
中科院分区：
文献类型：
--
作者：
Ochoa, R;Zárate, A;Basurto, L
目的：确定脐带血清瘦素和生长激素轴的成分-生长激素（GH）、总（t）和游离（f）胰岛素样生长因子（IGF）、IGF结合蛋白-3（IGFBP-3）和胰岛素-是否与出生体重相关。设计图：对22名新生儿（12名正常出生体重（NBW）和10名低出生体重（LBW））进行了横断面研究，这些新生儿来自一个明显正常妊娠的健康母亲群体。方法：在阴道分娩时采集母儿配对血样，测定瘦素和生长激素轴成分。结果如下：在所有情况下，母体血液中的瘦素，t和fIGF-I，其载体蛋白IGFBP-3和胰岛素浓度均高于新生儿的脐带血清，无论其出生体重如何。相反，母亲的GH水平低于新生儿。LBW新生儿的瘦素、tIGF-I和IGFBP-3水平较NBW新生儿降低;然而，GH浓度在LBW新生儿中较高。出生体重与脐带血瘦素、tIGF-I、IGFBP-3和GH显著相关，但出生体重与fIGF-I和胰岛素水平均不相关。结论：这些数据表明，出生体重与瘦素和生长激素轴的一些组件显着相关;另一方面，瘦素浓度和生长激素轴的每个组件之间没有相关性。提示胎儿瘦素和生长激素轴在胎儿宫内生长和出生体重中起协同作用。版权所有（C）2001 S. Karger AG，巴塞尔。
Objective: To determine whether cord sera leptin and components of the somatotropin axis-growth hormone (GH), total (t) and free (f) insulin-like growth factor (IGF), IGF-binding protein-3 (IGFBP-3), and insulin - correlate with birth weight. Design: Cross-sectional study of 22 newborns, 12 with normal birth weight (NBW) and 10 with low birth weight (LBW), in a population of healthy mothers with an apparent normal pregnancy. Methods: Paired mother-neonate blood samples were obtained at vaginal delivery in order to measure leptin and the somatotropin axis components. Results: In all cases maternal blood concentrations of leptin, t and fIGF-I, its carrier protein IGFBP-3, and insulin were higher than in the cord sera of the newborns, regardless of their birth weight. On the contrary, maternal GH levels were lower than in their neonates. LBW neonates had decreased levels of leptin, tIGF-I, and IGFBP-3 as compared with those levels in NBW offspring; however, GH concentrations were higher in LBW neonates. Birth weight showed a significant correlation with cord sera leptin, tIGF-I, IGFBP-3, and GH; nevertheless birth weight was neither interrelated with fIGF-I nor with insulin levels. Conclusion: These data demonstrate that birth weight is significantly correlated with both leptin and some components of the somatotropin axis; on the other hand, no correlation was observed between leptin concentrations and each one of the components of the somatotropin axis. It is suggested that fetal leptin and the somatotropin axis cooperate in intrauterine growth and birth weight. Copyright (C) 2001 S. Karger AG, Basel.