Patterns of infiltration of lymphocytes into the testis under normal and pathological conditions in mice
Patterns of infiltration of lymphocytes into the testis under normal and pathological conditions in mice
复制标题
DOI：
10.1111/j.1600-0897.2007.00556.x
复制
发表时间：
2008-01-01
影响因子：
3.6
通讯作者：
Itoh, Masahiro
中科院分区：
文献类型：
--
作者：
Naito, Munekazu;Itoh, Masahiro
睾丸被认为是免疫特权器官。特别是，Sertoli细胞形成的血-睾丸屏障保护自身免疫的精子细胞免受自身免疫系统的攻击。我们从诱导炎症细胞反应的角度对小鼠睾丸组织的微观状态进行了综述。许多研究表明，在男性生殖器官中，睾丸对各种形式的非自身免疫性炎症的抵抗力最强。然而，研究发现，即使在没有佐剂的情况下，用睾丸抗原免疫小鼠也可以诱导自身免疫性睾丸炎症。特别是，直小管由特定区域组成，淋巴细胞在该区域被吸引。在正常情况下，许多提呈抗原的巨噬细胞优先聚集在TR周围。巨噬细胞的这种特征积累是后天的现象，当精子细胞开始在生精小管中分化时就完成了(S)。此外，在正常小鼠的TR区、睾丸网区(R)、附睾区(E)可见与生殖细胞及其残留物关系密切的管内淋巴细胞，而在S体内则未见。虽然这些穿透性淋巴细胞的生理功能尚不清楚，但我们认为在某些病理条件下，这种微观状态可能会引起TRR、R和E的自身免疫性炎症。
The testis is known as an immunologically privileged organ. In particular, the blood-testis barrier formed by Sertoli cells protects auto-immunogenic spermatids from attack by the self-immune system. We review here the micro-status of testicular tissues in mice from the viewpoint of induction of inflammatory cell responses. Many studies have demonstrated that the testis is the most resistant to various forms of non-autoimmune inflammation among the male reproductive organs. However, it was found that testicular inflammation of autoimmune origin is inducible by immunization with testis antigens even without an adjuvant in mice. In particular, the tubuli recti (TR) comprises specific region, where lymphocytes are attracted. Many antigen-presenting macrophages preferentially accumulate around the TR under normal conditions. This characteristic accumulation of macrophages is an acquired phenomenon that is completed when spermatids start to differentiate in the seminiferous tubules (S). In addition, intra-tubular lymphocytes that are very close to both germ cells and their remnants could be occasionally found in the TR, rete testis (R), epididymis (E), but not in the S, in normal mice. Although the physiological function of these penetrating lymphocytes remains unknown, we suppose that this micro-status provides a chance for evocation of autoimmune inflammation of the TR, R and E in some pathological conditions.