A proposal of decision tree to screen putative antidepressants using forced swim and tail suspension tests
A proposal of decision tree to screen putative antidepressants using forced swim and tail suspension tests
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DOI：
10.1016/j.bbr.2005.06.015
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发表时间：
2005-11-07
影响因子：
2.7
通讯作者：
David, DJP
中科院分区：
文献类型：
--
作者：
Bourin, M;Chenu, F;David, DJP
在最常用的抑郁症行为动物模型：悬尾试验（TST）和强迫游泳试验（FST）中报告了品系间小鼠对抗抑郁药物反应的变异性。在两个试验中检查小鼠的行为，以筛选具有不同生化作用机制的各种抗抑郁药。以前的研究表明，药物敏感性取决于菌株和使用的测试。瑞士小鼠是检测血清素和/或去甲肾上腺素抗抑郁药的最敏感品系，而C57 BL/6 J是使用FST对安非他酮（多巴胺能药物）敏感的唯一品系。在TST中，所有研究的抗抑郁药都减少了Swiss和C57 BL/6 J菌株的不动时间。抗抑郁样活性的检测可以仅使用一种试验（瑞士小鼠的TST或瑞士和C57 B1/6 Rj小鼠的EST）进行，但两种试验都是得出作用机制结论所必需的。(c)2005 Elsevier B. V.保留所有权利。
Interstrain mice variability in response to antidepressant drugs has been reported in the most commonly utilized behavioural animal models of depression: the tail suspension test (TST) and the forced swimming test (FST). The behaviour of mice was examined in both tests for screening various antidepressants with different biochemical mechanism of action. Previous studies have revealed that drug sensitivity depends on the strain and test used. Swiss mice is the most sensitive strain to detect serotonin and/or noradrenaline antidepressants whereas C57BL/6J was the only strain sensitive to bupropion (dopaminergic agent) using the FST. In the TST, all antidepressants studied decreased the immobility time in Swiss and C57BL/6J strains. Detection of an antidepressant-like activity could be performed using only one test (TST with Swiss mice or EST with Swiss and C57B1/6 Rj mice), but both tests are necessary to conclude on the mechanism of action. (c) 2005 Elsevier B.V. All rights reserved.