Integrin-associated protein is a ligand for the P84 neural adhesion molecule
Integrin-associated protein is a ligand for the P84 neural adhesion molecule
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DOI：
10.1074/jbc.274.2.559
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发表时间：
1999-01-08
影响因子：
4.8
通讯作者：
Narayanan, V
中科院分区：
文献类型：
--
作者：
Jiang, PH;Lagenaur, CF;Narayanan, V
P84(也称为SHPS-1、BIT和SIRP)是一种参与受体酪氨酸激酶信号转导的异嗜性粘附膜蛋白，存在于哺乳动物中枢神经系统和非神经组织的突触中。我们已经使用表达克隆策略确定了P84的结合伙伴。在此，我们报道了整合素相关蛋白(IAP/CD47)是P84的主要结合伙伴。免疫组织化学显示P84和IAP在成人大脑的不同区域中的分布几乎相同。由于IAP参与了免疫系统细胞的细胞信号传递，P84和LAP是一对异嗜性结合对，可能参与突触和其他组织的双向信号传递。
P84 (also known as SHPS-1, BIT, and SIRP) is a heterophilic adhesive membrane protein involved in receptor tyrosine kinase signaling that is found at synapses in the mammalian central nervous system and in non-neural tissues. We have identified a binding partner for P84 using an expression cloning strategy. Here we report that integrin-associated protein (IAP/CD47) is a predominant binding partner of P84. Immunohistochemistry reveals a virtually identical distribution of P84 and IAP in a variety of adult brain regions. Because IAP has been implicated in cell signaling in cells of the immune system, P84 and LAP represent a heterophilic binding pair that is likely to be involved in bi-directional signaling at the synapse and in other tissues.