Beclomethasone diproprionate for severe asthma during pregnancy.
Beclomethasone diproprionate for severe asthma during pregnancy.
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二丙酸倍氯米松用于妊娠期间严重哮喘。
DOI：
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发表时间：
1983
影响因子：
39.2
通讯作者：
R. Patterson
中科院分区：
文献类型：
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作者：
P. Greenberger;R. Patterson
在40名女性的45次怀孕期间评估了使用吸入性二丙酸倍氯米松治疗妊娠期间严重哮喘的安全性。尽管长期服用茶碱，并且在一些女性中服用麻黄碱，但哮喘非常严重，以至于皮质类固醇对于防止急诊室就诊和哮喘持续状态至关重要。在受孕时，在38例妊娠中定期使用二丙酸倍氯米松，在另外4例妊娠的前三个月开始使用。丙酸倍氯米松吸入剂的范围为4 - 16/d，平均为9.5/d（336 μ g）。在37例妊娠中，泼尼松给药是必要的。5名妇女发生哮喘持续状态，但没有母亲或胎儿死亡。一名患有糖尿病和精神分裂症的妇女所生的婴儿发生心脏畸形，其妊娠并发糖尿病酮症酸中毒和哮喘持续状态。尚不清楚二丙酸倍氯米松是否是这些畸形的原因。先天性畸形的患病率（1/43例活产）在正常范围内，表明当使用推荐剂量时，在妊娠期间使用二丙酸倍氯米松治疗是安全的。
The safety of using inhaled beclomethasone dipropionate for the treatment of severe asthma during pregnancy was evaluated during 45 pregnancies in 40 women. Despite chronic administration of theophylline and, in some women, ephedrine, the asthma was so severe that corticosteroids were essential to prevent emergency room visits and status asthmaticus. At conception, beclomethasone dipropionate was being used regularly during 38 pregnancies and was initiated during the first trimester in 4 other pregnancies. The range of beclomethasone dipropionate inhalations was 4 to 16/d with a mean of 9.5/d (336 micrograms). Prednisone administration was necessary during 37 pregnancies. Status asthmaticus occurred in five women but no mothers or fetuses died. Cardiac malformations occurred in an infant born to a woman who was diabetic and schizophrenic whose pregnancy was complicated by diabetic ketoacidosis and status asthmaticus. It is not known whether beclomethasone dipropionate was the cause of these malformations. The prevalence of congenital malformations (1 of 43 live births) is within the normal range and shows that treatment with beclomethasone dipropionate is safe during pregnancy when recommended doses are used.